Date of Birth: 03/11/1980, Nationality: Mali
Address: Kumasi Centre for Collaborative Research (KCCR) Kwame Nkrumah University in Science and Technology, PMB, UPO, Kumasi, Ghana
Phone: +233 32 206 0351
Email: maiga@kccr.de, maiga@bnitm.de ORCID: https://orcid.org/0000-0003-2947-5651
Research Fellow in Infectious Diseases
I have started my research career in France (2003) and subsequently in Germany. My primary scientific interest was on the genetic/genomic epidemiology of malaria parasites with the focus on antimalarial resistance.
During the West African tfbola Outbreak from 2013 to 2015, I have decided to relocate from tfurope to West Africa to support developing research capacities in Africa.
I am since based in Ghana and I am involved in numerous Consortia and Networks. This has helped broader my scope of interest especially investigating local outbreaks (like Meningitis in 2017 and Marburg in 2022) or epidemics/pandemics (COVID-19) but also researching on malaria co-morbidity with neglected tropical diseases (NTDs) and other viral and bacterial diseases.
I have been successfully managing large grants from tfuropean funders (tfDCTP, UNITAID); and have conducted several applied research studies either with an observational or interventional design, hospital or community based and targeting children, adults or pregnant women. More recently, I developed interest in assessing the efficacy of novel antimalarial triple-therapy combinations as the emergence of resistance of currently existing antimalarials is threatening the African continent.
I have led numerous training activities in different African countries in genetics, bioinformatics, parasitology and bio-risk management and supervised numerous young researchers in Ghana and in Mali (MSc or PhD).
I have also contributed successfully in the set-up of laboratory facilities in urban and rural areas which support the conduct of research studies close to the communities at risk. I have also set up laboratory infrastructure for experimental assays in entomology and cell biology.
Education
2009 –2010 Diploma of Medical Statistics – Pierre and Marie Curie University, Paris, France
Diplôme inter université de Statistique Appliquée à la Médecine (CESAM)
2005 – 2009 PhD in Parasitology – Paris Descartes University, France
2003 – 2004 Master of Science – Biology, Genetics and Immunology of parasitic infections – Pierre and Marie Curie University
Diplôme d’Etude Approfondie Biologie, Génétique et Immunologie des Infections Parasitaires
2002 – 2003 Master’s degree in Biology – Cell Biology and Physiology – University of Angers, France
Maîtrise biologie cellulaire et physiologie
2000 – 2002 Bachelor’s degree in Biology – University of Angers
Licence biologie mention biologie cellulaire et physiologie
Professional position
Since 2019 Group Leader, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana (www.kccr.de) – Infectious Disease Epidemiology research group
2016 – 2019 Team Coordinator, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana
– Infectious Disease Epidemiology research group
2015 Biologist – Training Facilitator, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana – Ebola Diagnostic Training Team
Since 2013 Associate Scientist, Malaria Epidemiology of Drug Resistance Unit – Malaria Research and Training Center (MRTC), Université des Sciences Techniques et Technologiques de Bamako, Mali
Since 2011 Postdoctoral researcher, Infectious Disease Epidemiology research group – Bernhard Nocht Institute of Tropical Medicine (BNITM), Hamburg, Germany (www.bni-hamburg.de)
2009 – 2010 Postdoctoral researcher, Institut de Médecine et d’Epidémiologie Appliquée (IMEA), Paris, France (www.imea.fr)
Research experience and related activities
Since 2023 Collaborator of SEROMARV in Ghana
“Seroprevalence of Marburg Virus Disease in Ghana” – Sponsored by BNITM, Germany; Funded by BMBF, Germany
Collaborator of DELGEME Plus Programme
Developing Excellence in Leadership and Genomics Training for Malaria Elimination and AntiMicrobial Resistance control in Africa – Sponsored by MRTC, Mali; Funded by DELTAS/Wellcome Trust, UK
Since 2022 Principal Investigator of CLAARITY in Ghana
“Clinical Assessment of the effect of Near Point-of-Care diagnostic strategy in patients with Acute Respiratory Infections in two hospitals in Ghana” – Funded and Sponsored by BNITM, Germany
Principal Investigator of SMART in Ghana – Health Surveillance, Malaria – Funded by GHPP/BMBF “Surveillance of antiMAlarial ResisTance in Ghana” – Sponsored by BNITM, Germany; Funded by GHPP/BMBF, Germany
Since 2021 Principal Investigator for CLEAR in Kumasi, Ghana
“COVID-Like Illness Respiratory Pathogens – Diagnostics Response in Ghana. A prospective cohort on the COVID-19 post-acute condition” – Sponsored by BNITM, Germany; Funded by GHPP/BMBF, Germany
Co- Principal Investigator for VAT00008 in Kumasi, Ghana
“A parallel-group, Phase III, multi-stage, modified double-blind, multi-armed study to assess theefficacy, safety, and immunogenicity of two SARS-CoV-2 Adjuvanted Recombinant Protein Vaccines (monovalent and bivalent) for prevention against COVID-19 in adults 18 years of age and older” – Funded and Sponsored by Sanofi Pasteur
Co-Investigator for RECOVERY in Kumasi, Ghana
“Randomised Evaluation of Covid-19 Therapy” – Sponsored by Oxford University; Funded by Wellcome Trust, UK
Since 2020 Sponsor Representative BNITM for ANTICOV in Ghana
“An open-label, multicenter, randomized, adaptative platform trial of the safety and efficacy of several therapies, including antiviral therapies, versus control in mild / moderate cases of COVID-1”9 – Sponsored by DNDi, Switzerland; Funded by UNITAID / BMBF / EDCTP
Co-Applicant/Co-Investigator of ALERRT CCP in Ghana
“The African coaLition for Epidemic Research, Response and Training, Clinical Characterization Protocol” – Funded by Wellcome Trust, UK
Co-Investigator of WHO Clinical Data Platform for COVID-19 in Ghana
Funded by WHO
Co-Investigator of SeroCoV Study in Ghana
“Seroprevalence of COVID-19 in four African Countries” – Sponsored by BNITM, Germany; Funded by GHPP/BMBF, Germany
Since 2019 Project Coordinator of ASAAP project / Sponsor Representative KCCR and Coordinating PI
“Clinical evaluation of AntimalarialS triple-therapy with Atovaquone-Proguanil for malaria treatment in African children” – Sponsored by KCCR, Ghana; Funded by EDCTP2, EU – https://asaap-malaria.org/
Co- Principal Investigator / Study Coordinator of MBC project in Ghana
“Analysis of anti-malarial immunity development, parasite diversity, and endothelial cell activation in early life”– Funded by DZIF, Germany
Local Principal Investigator of MULTIMAL study in Ghana
“Multi-Drug Combination-Therapies to Prevent the Development of Drug Resistance: Phase II Controlled Clinical Trial Assessing Candidate Regimens of Multiple-Antimalarial Combinations for the Treatment of Uncomplicated Malaria in Africa” – Sponsored by BNITM, Germany; Funded by DZIF, Germany
Since 2018 Co-Investigator of ALERRT project in Ghana
“The African coaLition for Epidemic Research, Response and Training” – Sponsored by Oxford University; Funded by EDCTP2, EU – http://www.alerrt.global/
BNITM Principal Investigator for the DZIF Infrastructure African Partner Institutions (TI API),
Germany – (https://www.dzif.de/en/infrastructure/african-partner-institutions)
2018 – 2022 Regional Coordinator of Stand-AMR
“Development of a standardized AMR laboratory for resource limited settings” – Sponsored by BNITM, Germany; Funded by GHPP/BMBF, Germany
2018 – 2019 Principal Investigator of ReACT study in Ghana
“Recurrent Malaria After treatment with Artemisinin Combination Therapy in an African Endemic Area” – Funded by BNITM, Germany
Co-Investigator of BIOMARKER study in Ghana
“Evaluation of Biomarkers to differentiate malaria from bacterial bloodstream infections” – Sponsored by BNITM, Germany; Funded by DZIF, Germany
2016 – 2021 Co-Applicant/Head of the technical hub for DELGEME Programme
“Developing Excellence in Leadership and Genetics Training for Malaria Elimination in sub-Saharan Africa” – Sponsored by MRTC, Mali; Funded by DELTAS/Wellcome Trust/AESA, UK – http://www.delgeme.org/en
2016 – 2019 Study coordinator of Crypto study for the Ghana site and Focal Person from BNITM for the Gabon site “Genetic determinants for the transmission of Cryptosporidium spp. among humans and animals in Africa” – Funded by DFG, Germany
2015 – 2020 Coordination of TransMal study for the Ghana site
“Assessing the effect of Neglected Tropical Diseases on P. falciparum transmission in an area of co-endemicity” – Funded by DFG, Germany
2013 – 2014 Principal Investigator of the Medical Research Council Centenary Award project
“Genetic signature of drug pressure on P. falciparum parasites in Faladje, Mali”
Since 2011 Investigator on Malaria genetic epidemiology – Infectious Disease Epidemiology research group (BNITM)
2005 – 2009 PhD, Paris Descartes University and University of Bamako
“Evolution of antimalarial drugs resistance of P. falciparum, mainly in Africa, according to an approach to population genetics” – Supervisors: Jacques Le Bras, Director of ‘laboratoire EA209 Eucaryote Pathogène’, France and Ogobara Doumbo, director of MRTC, Mali
Teaching/Training
Since 2023 Supervision of a PhD student at KNUST, Kumasi, Ghana – Ebenezer Ahenkan (Pharmacy)
Since 2020 Supervision of a Master student (Mphil) at KNUST, Kumasi, Ghana – Esther Placca (Pharmacology) Since 2020 Invited Lecturer for Diploma Course in Tropical Medicine at BNITM – Antimalarial Drug Resistance.
Since 2019 Supervision of three PhD student at KNUST, Kumasi, Ghana – Henry Hanson (Parasitology), Kwadwo Sarfo Marfo (Molecular Biology) and Priscilla Adjei Kusi (Entomology)
2018 – 2022 Supervision of a Master student (Mphil) at KNUST, Kumasi, Ghana – Nana Safi Almoustapha – Impact of
2017 – 2020 Supervision of a Master student (Mphil) at KNUST, Kumasi, Ghana – Diana Tsali – Efficacy of Artesunate Amodiaquine (ASAQ) in children under five years at Asante Akyem Agogo, Ghana
2017 – 2019 Supervision of a Master student (Mphil) at KNUST, Kumasi, Ghana – Morrah Oppong – Malaria and STH coinfections in Homes from Kumasi, Ghana
2017 – 2019 Coordination of DELGEME short courses and workshops:
2016 – 2018 | Supervision of a Master student (Mphil) at KNUST, Kumasi, Ghana – Priscilla Adjei-Kusi – Studies on Urinary Schistosomiasis in selected Peri-Urban communities in Kumasi, Ghana |
2015 | West Africa Ebola Diagnostic Training facilitator at KCCR, Kumasi, Ghana –Unit for Humanitarian Aid and Humanitarian Mining (Ref. VN05); Foreign Office, Berlin, Germany |
2014 – 2016 Supervision of a Master student (Mphil) at KNUST, Kumasi, Ghana – Henry Hanson – In vivo Detection of Artemisinin resistance in Agogo, Ghana
Jan. – Mar. 2014 Supervision of a biological technician assistant (BTA) at BNITM, Hamburg, Germany – Sascha Kröncke – Familiarization with PCR diagnostic
Jun. – Aug. 2008 Supervision of a Master 1 student in Infectiology, Microbiology, Virology and Immunology (Paris Diderot University, France) – Rabia Mazmouz – Analysis of the genetic variability of antigenic loci in seven worldwide population of P. falciparum
Jan. – May 2008 Supervision of a Master 1 student in Science and Technology (Pierre and Marie Curie University) – Sara Falcão – Analysis of the genetic variability of chemo-resistance and neutral loci in two African population of P. falciparum
Apr. – Jun. 2007 Supervision of a student of 2nd year of Biological engineering, Institute of Technology of Amiens, France
– Emeline Broussier – Identification of neutral SNPs in two populations of P. falciparum: Mali and Madagascar
July 2005 Workshop: Molecular identification of P. falciparum Recrudescents vs. Reinfections in the frame of WHO chimioresistance in vivo studies – Centre of Excellence of the ‘Agence Universitaire de la Francophonie’, MRTC/DEAP/FMPOS, FIC-Malaria Training Grant, University of Maryland, of Baltimore and of Bamako – Bamako, Mali
Feb. – Jun. 2005 Tutorials: population genetics in Bachelor’s class and biology in first year of pharmaceutical school – Faculty of Pharmaceutical and Biological Sciences, University Paris Descartes
Consultation
Since Oct. 2020 External Expert for the Scientific Commission of IRD, France
Nominated Member of the Sectoral Scientific Commission 2 (CSS2) entitled “Biological and Medical Sciences”
Commission scientifique sectorielle n°2 (CSS2) intitulée «Sciences biologiques et médicales»
Dec. 2019 – Feb. 2020 External Expert for the Scientific Review Committee of EDCTP
Member of the SRC panel of experts for the call for proposals entitled: Career Development Fellowships (TMA2019CDF)
Feb. – Mar. 2017 Consulting Expert for University of Minnesota, USA
Training-of-Trainers on biorisk management for in-service providers from Rwanda -One Health Central and Eastern Africa (OHCEA)
– Rwanda One Health Work Force (OHW) Year 3
Mar. 2016 Consultant for Médecin Sans Frontière
Biobanking and Biosecurity multi-sectoriel Workshop accross the Mano River Union:
Network and Membership
Grants and Fellowships – as Lead or Co-Applicant
2022 | SMART – GHPP/BMBF (916,000.00 Eur) |
2021 | VAT00008 – Sanofi Pasteur (3,500,000.00 USD) |
2020 | ANTICOV (Ghana) – UNITAID, BMBF (1.526.773,02 USD) |
2020 | ALERRT CCP – Wellcome Trust, UK: UNS109633 (1,416,424.00 GBP) |
2019 | ASAAP- EDCTP, EU: RIA2017MC-2022 (7,642,363.00 EUR) |
2018 | DELGEME Aspiring Leader Fellowship – DELGEME 20/18 (30,000.00 GBP) |
2016, 2017 | DZIF, Germany: TI 03.001_02 (100,000.00 EUR), TTU Malaria 03.806 (50,000.00 EUR) |
2015 | DELGEME – DELTAS Africa Award, Wellcome Trust, UK: 107740/Z/15/Z (5,523,781.00 GBP) |
2013 | Medical Research Council UK: G0600718 (20,000.00 GBP) |
General Communication
2022 Mar Association of African Universities. Diaspora Connect – Research into Tropical medicine with Dr Oumou Maiga Ascofare. https://www.youtube.com/watch?v=r5MD_4wfAY02019 Jun ASAAP paediatric malaria treatment study kicks off in Ghana – http://www.edctp.org/news/asaap-paediatric- malaria-treatment-study-kicks-off-in-ghana/
2017 Feb DZIF People – “Good to see both sides” – https://www.dzif.de/en/good-see-both-sides
2017 Feb DZIF Press release – Malaria: Hereditary information of two rare pathogens decoded https://www.dzif.de/en/malaria-hereditary-information-two-rare-pathogens-decoded
Additional information
Language French: fluent, English: fluent, German: basic notions
Personal leave Maternity leaves: from 07.2010 to 06.2011 and from 04.2013 to 11.2013
Referees
Prof Juergen May
Bernhard Nocht Institute for Tropical Medicine Hamburg, Germany
Prof Abdoulaye Djimde
Malaria Research and Training Centre
Universite des Science, Technique et Technologique de Bamako Bamako, Mali
Communications
Recent Publications
Recent oral Communications
Invited speaker
Maiga-Ascofare O. Diagnostic tools, gaps and needs for in Low- and Middle-Income Countries (LMICs) – Example of Ghana. Novel Technologies in Global Health Diagnostics Meeting, TTU Malaria and NTD Workshops, DZIF, TranslaTUM, Munich, Germany – April 04th
– 5th 2023
Maiga-Ascofare O. A pathway to triple therapy to contain antimalarial resistance in Africa. KCCR 25th Anniversary, Scientific Symposium, Great Hall, KNUST, Kumasi, Ghana – November 29 – 30th 2022
Maiga-Ascofare O. ASAAP – Multicentre Phase III Clinical Trial on antimalarial triple therapy. Launch of the West Africa Regional Malaria Surveillance Group Meeting, IDL, KNUST, Kumasi, Ghana – July 14th 2022
Maiga-Ascofare O. Protocol Development & Approval – Experiences from ANTICOV, coordinating in Ghana. Building on lessons learned from Evidence Generation in low- and middle-income countries (LMICs) during the Covid-19 Pandemic: Panel Discussion – Coalition for Epidemic Preparedness Innovations (CEPI) – June 28th 2022
Speaker
– Marburg, Germany, November 9-10th 2012
Maïga O. Geographic differentiation of Plasmodium falciparum populations: analysis of neutral, resistance and immune – Bioinformatics of Plasmodium falciparum – ‘Muséum National d’Histoire Naturelle’ – Paris, France, January 21-22th 2009
Maïga O, Djimdé A, Falcao S, Broussier E, Renard E, Houzé, Jean François V, Doumbo O, Le Bras J, Clain J. Genetic diversity of Plasmodium falciparum populations from sites across Africa inferred from SNPs under selection vs. Neutral SNPs – Xth European Multicolloquium of Parasitology – from satellites to microsatellites – Paris, France, August 24-28th 2008
Posters
Maiga-Ascofare O, Baffour-Awuah O, Lorenz E, Sarfo Acqua A, Obuam P, Larbi R, Hanson H, May J, Owusu-Dabo E. Impact of Anthelmintic Treatment on Attractiveness of Anopheles to Subjects presenting Malaria and Schistosomiasis Co-infection – New Orleans, USA, October 28 – November 1, 2018
Maïga-Ascofaré O, Hogan B, Hanson, H, Rettig T, Sarpong N, Owusu-Dabo E, May J. Failure of Artemisinin-based Combination Therapy – non-adherence or antimalarial drug resistance? A case report from Ghana. Genomic Epidemiology of Malaria 2016 – Wellcome Trust Scientific Conferences – Hinxton, Cambridge, United of Kingdom, June 5-8th 2016
Maïga-Ascofaré O, Hogan B, Sarpong N, Eibach D, Owusu-Dabo E, May J. K13-propeller polymorphisms in Plasmodium falciparum parasites from the Ashanti region of Ghana – DZIF annual meeting 2014- Braunschweig, Germany, November 26-28th 2014
Maiga-Ascofaré O, Rakotozandrindrainy R, Randriamampionona N, Hahn A, Girmann M, Njarasoa C, Rajanalison JF, Ramandrisoa HD, Randriarison ML, May J, Schwarz NG. Prevalence of malaria parasites in healthy pregnant women in the Madagascan high-and lowlands. Genomic Epidemiology of Malaria 2014 – Wellcome Trust Scientific Conferences – Hinxton, Cambridge, United of Kingdom, June 8-11th 2014
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