Global Health & Infectious Diseases

The Group is committed to advancing research which promotes One Health – rooted in scientific exploration of the complex inextricable link between humans, other animals and the environment we share. Working closely with diverse partners at local, regional and global levels, RG Global One Health integrates epidemiology, clinical research, laboratory science, and implementation research to generate evidence for improved prevention, diagnosis, and treatment of diseases.
RG Global One Health is focussed on equitable and impactful global health research and so invests in capacity building – training the next generation of scientists and health professionals, while linking research outputs to policy and public health action.

African coaLition for Epidemic Research, Response, and Training (ALERRT)

Summary of Project Aims: ALERRT is a multi-disciplinary consortium building a patient-centered clinical research network to respond to epidemics across sub-Saharan Africa. ALERRT aims to reduce the public health and socio-economic impact of disease outbreaks in sub-Saharan Africa by building a sustainable clinical and laboratory research preparedness and response network. ALERRT consists of 21 partner organizations from 13 countries (9 African and 4 European). ALERRT combines the strengths of leading African and European partners in epidemic-prone infectious diseases research. We are committed to delivering an agile research response that supports national, regional, and global health security initiatives. The Work package 4 of ALERRT is being led by KCCR and is working towards establishing a response framework that alleviates administrative, regulatory, and ethical bottlenecks and mobile-research capabilities that together ensure ALERRT can act swiftly to initiate fit-for-purpose clinical and laboratory research in varying settings within SSA in case of actual REPID threat. 


RECOVERY Clinical Trial

Summary of Project Aims: RECOVERY is a randomized control trial among hospitalized adults to investigate the effect of different therapies for Covid-19 disease. The randomized trial among patients hospitalized for Covid-19 was conducted in two study sites (KATH, Kumasi, and GA EAST, Accra). All eligible patients were randomly allocated between several treatment arms, each to be given in addition to the usual standard of care in the participating hospital.


Lancet One Health Commission (LOHC)

Summary of Project Aims: The One Health Lancet Commission is hosted by the Centre for Global Health at the University of Oslo (UiO). The aim of the Commission is to synthesize the evidence supporting a One Health approach to enhancing health within an environment shared by humans and animals. The commission’s work explicates the significance of a One Health approach for policy, by engaging transdisciplinary expertise and perspectives from both the public and private sectors. The Lancet One Health Commission is co-chaired by Prof. John Amuasi, Kumasi Centre for Collaborative Research in Tropical Medicine at the Kwame Nkrumah University of Science and Technology, Ghana, and Prof. Andrea Winkler, Centre for Global Health at UiO and Center for Global Health at the Technical University of Munich. A core group comprising staff from the Centre for Global Health at UiO, WHO and Imperial College is driving the direction, design, and implementation of the Commission. 


The Global Health Network (TGHN) Artificial Intelligence-Ghana hub

Summary of Project Aims: 1. to establish a locally led high quality Centre for The Global Health Network to advance knowledge mobilization, through the active sharing of resources, and the dissemination of research activities; 2. to contribute to the understanding of the research landscape, existing capacity and challenges faced with research in the country; 3. to build and engage a community of practice for the country; 4. to promote TGHN in the country and the Region; engaging wider groups and communities in the related activities; 5. to facilitate training initiatives to support and strengthen the research environment: supported learning sessions, research clubs, data clinics; 6. to seek and collaborate on further joint research grant proposals, building on local and regional partnerships.


Snakebite Incidence, Treatment and Effects in Ghana (SnakebITE)

Summary of Project Aims: 1. to establish a more accurate estimate of the national burden of snakebite envenoming (SBE); 2. to fill the missing gap of data on treatment seeking, current treatment practices and clinical and health outcomes of SBE; 3. to provide critical information for determining stocking and informed distribution of antivenoms in Ghana; 4. to assess the cost of illness of SBE; 5. to develop and implement locally relevant behavior change communication tools for community-based snakebite prevention and management.


Severe neonatal adaptive platform trials in Africa (SNIP-Africa)

Summary of Project Aims: The SNIP-AFRICA is a multi-country multi-centre project that focuses on high-burden, high impact group of inpatient neonates and infants with sepsis. This is a group especially affected by escalating rates of AMR in sub-Saharan Africa (SSA) healthcare facilities contributing to much slower than desirable improvements in neonatal mortality across SSA. The project therefore aims to establish a clinical research network and architecture to implement adaptive platform trials in SSA, responding to the urgent need for improved treatment of childhood infection in an era of increasing antimicrobial resistance (AMR). The Global Health and Infectious Diseases Research group will lead the Capacity Building Work Package for the SNIP-AFRICA Consortium.


Africa Snakebite Alliance (ASA)

Summary of Project Aims: The ASA project aims to improve health outcomes for people affected by snakebite envenoming by addressing evidence gaps in policy and practice in Africa.


Collaborative AI-Driven Resource for Expectant Mothers with Diabetes (C.A.R.E GDM) (formerly RAID-MaP-Gh)

Summary of Project Aims: The C.A.R.E GDM project aims to develop an AI-powered clinical decision support tool. The tool will assist less experienced clinicians and under-resourced healthcare providers in managing complications and comorbidities in pregnancies, with a focus on pregestational and gestational diabetes mellitus.


Promoting Systematic and Transparent Use of Evidence in One Health Policy Decision-Making in Ghana (OH-EVI)

Summary of Project Aims: This project aims to bring together key stakeholders to foster long-term collaboration between research producers and users. The goal is to bridge the gap between technical expertise and policymaking to enhance the uptake of research in policy processes, increasing the visibility and prioritization of One Health topics at the national, regional, and global levels.


An open label randomized controlled trial comparing novel combination and currently used antibiotic regimens for the empiric treatment of neonatal sepsis with a run-in confirmatory pharmacokinetic phase (NEOSEP1)

Summary of Project Aims: The study will take place at the MBU (Mother and Baby Unit) at KATH, with a target of recruiting 50 participants per year for 4 years. A written informed consent will be obtained from parents/guardians prior to the commencement of any trial-related procedure. The sheet will be read aloud to those who are unable to read, and the written consent form signed by an independent witness where parents are not able to sign their name but provide only a thumbprint. Consent will be sought again if a neonate’s legal guardian changes. Neonates for whom the trial is medically appropriate, based on the inclusion criteria, will be considered for the study. Participants will be randomized, and treatment initiated on the same day, if possible. The study hypothesizes that mortality in hospitalized neonates with sepsis can be reduced by choosing a top-ranked antibiotic regimen compared with the World Health Organization (WHO) recommended empiric antibiotic regimens for neonatal sepsis and other currently used regimens.
The study aims to prove that mortality in hospitalized neonates with sepsis can be reduced by choosing a top-ranked antibiotic regimen compared with the World Health Organization (WHO) recommended empiric antibiotic regimens for neonatal sepsis and other currently used regimens. 


Chronic Infections in Hypertensive dIsorders of Pregnancy (preeclampsia) And Colorectal CArcinoma (CHIPCA)

Summary of Project Aims: Schistosomiasis affects over 230 million people globally, with Ghana bearing a significant burden despite ongoing mass drug administration. In partnership with Komfo Anokye Teaching Hospital, Klinikum Rechts-der-Isar, and the Kumasi Centre for Collaborative Research, we are establishing a schistosomiasis research hub in Kumasi. The HDP study will assess female genital schistosomiasis, hepatic dysfunction, metabolic abnormalities, and adverse pregnancy outcomes. The CRC study will investigate associations with colorectal cancer through clinical, biomarker, and endoscopic evaluations. Together, these efforts will generate translational evidence to inform clinical practice and policy in sub-Saharan Africa. 


Strengthening the global clinical research ecosystem for epidemic and pandemic prevention and preparedness (ISARIC 3.0)

Summary of Project Aims: The relevance of this grant is to support the project titled: “ISARIC 3.0: Strengthening the Global Clinical Research Ecosystem for Epidemic and Pandemic Prevention and Preparedness” by conducting annual training sessions under the theme: “Clinical Research During Outbreaks (CREDO)”. The award is to serve two purposes: CREDO training and Project Management of the CREDO training.


Collaboration for Research, Training and Implementation in Critical Care in Asia and Africa (CCAA)

Summary of Project Aims: The main aim of this study is to integrate critical care services in Ghana into an international research network that facilitates high-quality studies and helps identify effective interventions for improving outcomes in critically ill patients. 


Improving Patient Outcome Plan (IPOP)

Summary of Project Aims: This programme of work covers the development phase for a filovirus and an mpox Improving Patient Outcome Plan (IPOP). The programme sets out to produce filovirus and mpox IPOP proposals for Executive Board review, and conduct preparatory work including: 
• Landscape analysis
• Identification of the clinical problem 
• Identification of relevant target interventions 
• Proposed evaluation pathway 
• PPIE embedding 
• Availability and affordability mechanisms 
• Collaborative opportunities 
• PhD opportunities 


Epidemiology and assessment of health systems capacity to detect and manage schistosomiasis in urban communities in the Ashanti region of Ghana (Urban Schisto)

Summary of Project Aims: To determine the epidemiology and assess the capacity for the detection and management of schistosomiasis in urban areas in Ashanti region.


A phase II clinical trial investigating the potential of two oral drugs to act as new snakebite therapies against venom from the viperid family of snakes (TOCSINS)

Summary of Project Aims: The main aim of this grant is to provide scientific and clinical input to protocol development and trial design for the TOCSIN trial in Ghana.


Seroprevalence of Marburg Virus Infection and other WHO-priority pathogens in Three (3) Countries in Africa (ALERRT PLUS)

Summary of Project Aims: The primary objective of this study is to assess prior exposure to Marburg Virus (MARV) infection in the general population across three African countries by detecting circulating IgG antibodies. In addition, the study seeks to estimate the force of infection (FOI) for MARV,a measure of the risk of infection and the level of pathogen circulation, which can provide insights into the overall burden of MARV infection and disease. The study, conducted under the ALERRT Consortium through the Global Health and Infectious Diseases Research Group, is scheduled to run over a 12-month period. Active recruitment is currently ongoing in the three participating countries: Cameroon, Guinea, and Uganda.


The Platform Adaptive Randomised Trial for NEw and Repurposed Filovirus treatmentS trial (PARTNERS)

Summary of Project Aims: This project tasks GHID with responsibilities under the PARTNERS trial focus on co-leading its work Package 2 (PPIE), delivering national and regional engagement activities, and supporting ethics/regulatory submissions.

  • European and Developing Countries Clinical Trials Partnership (EDCTP)
  • Wellcome Trust (WT)
  • Oxford University (UO)
  • The Global Health Network (TGHN)
  • Liverpool School of Tropical Medicine (LSTM)
  • Science for Africa Foundation (SFA)
  • Global Antibiotic Research and Development Partnership Foundation (GARDP)
  • GIZ via Institut für Medizinische Mikrobiologie, Immunologie und Hygiene Technical University Munich (TUM)
  • Foreign, Commonwealth and Development Office (FCDO)
  • Royal Society of Tropical Medicine and Hygiene (RSTMH)
  • Children’s Investment Fund Foundation (CIFF)
  • Medical Research Council (MRC)
  • Bernhard Nocht Institute for Tropical Medicine (BNITM)
  • Task Force for Global Health (TFGH)
  • Drugs for Neglected Diseases initiative (DNDi)
  • German Institute for Global and Area Studies (GIGA)
  • Friedrich-Loeffler-Institut (FLI)
  • German Federal Ministry of Health (BMG)

2025

Pathfinder Studies: A Novel Tool for Process Mapping Data-Driven Health Research to Build Global Research Capacity

Uppal A, Kagoro F, Monteiro-Krebs L, Bueno FTC, Marques LP, Tessema SK, Amuasi J, Retford M, Baker B, Rumi M, Naheed A, Temfack E, Machado CV, Kiosia A, Kingpriest P, Lang T.

BMC Medical Research Methodology

Future Trajectories for One Health

Amuasi JH, Winkler AS

Lancet

The Lancet One Health Commission: Harnessing Our Interconnectedness for Equitable, Sustainable, and Healthy Socioecological Systems

Winkler AS, Brux CM, Carabin H, das Neves CG, Häsler B, Zinsstag J, Fèvre EM, Okello A, Laing G, Harrison WE, Pöntinen AK, Huber A, Ruckert A, Natterson-Horowitz B, Abela B, Aenishaenslin C, Heymann DL, Rødland EK, Berthe FCJ, Capua I, Sejvar J, Lubroth J, Corander J, May J, Roth LF, Thomas LF, Blumberg L, Lapinski MK, Stone M, Agbogbatey MK, Xiao N, Hassan OA, Dar O, Daszak P, Guinto RR, Senturk S, Sahay S, Samuels TA, Wasteson Y, Amuasi JH

Lancet

Burden of perceived stress among stroke survivors in Ghana: Insights from a multicentre, cross-sectional study

Darkwah JD, Albert A, Bockarie A, Ayisi-Boateng NK, Konadu E, Adu-Gyamfi R, Arthur A, Agyenim-Boateng K, Neizer C, Fiattor T, Opare-Addo P, Adusei-Mensah N, Tagge R, Ampofo M, Kwapong H, MacCready E, Agyei M, Akassi J, Amuasi JH, Nguah SB, Sarfo FS, Ovbiagele B. J

Journal of Stroke and Cerebrovascular Diseases

Exploring the Current Situation and Developing Strategies for Behavior Change to Improve Antibiotic Use in West Africa: Protocol for a Multidisciplinary Interventional Research Project

Neuerer M, Baxerres C, Dekker D, Bila B, Arhinful D, Aglanu LM, Akenten CW, Coulibaly B, Sié A, Amuasi JH, Souares A.

JMIR Research Protocols

Analysis of Knowledge, Attitudes, and Practices Related to Antibiotics and Antimicrobial Resistance Awareness among Community Members in Ghana and Burkina Faso

Cama I Gibernau E, Aglanu LM, Zakane A, Dekker D, Jahn A, Sié A, Amuasi JH, Souares A.

Antimicrobial Resistance & Infection Control

Snakebite Envenomation Through a Gender Intersectionality Lens in Low- and Middle-Income Countries

Ayesiga I, Naggayi S, Gmanyami JM, Akaka A, Kubwimana O, Gyabaah GA, Katusiime E, Hashim UM, Kahwa I.

Transactions of The Royal Society of Tropical Medicine and Hygiene

Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population.

Boakye AO, Obirikorang C, Afum-Adjei Awuah A, Adu EA, Winter D, Boham EE, Alani H, Newton SK, Almoustapha NST, Deke J, Dzadey WO, Adu-Amoah L, Kroduah SA, Grant MA, Asare G, Amoako-Adusei A, Loag W, Kettenbeil J, Sarkodie YA, Oduro-Mensah E, Yawson AE, Apanga S, Odotei Adjei R, Adobasom-Anane AG, Lorenz E, Souares A, Maiga-Ascofaré O, May J, Struck NS, Amuasi JH.

Frontiers in Genetics

The Promise and Compromise of The WHO Pandemic Agreement for Spillover Prevention and One Health

Finch A, Vora NM, Hassan L, Walzer C, Plowright RK, Alders R, Suit-B CY, Amuasi JH, Mulumba M, Loch-Temzelides T, Guerrero-Sanchez S, Gostin LO.

Lancet

Access Barriers to Healthcare Services among The Fulani Population in Ghana: A Qualitative Study in the Sissala East Municipality.

Bonney RA, Opoku D, Mensah KA, Amuasi JH, Dassah E, Emikpe BO, Waitzberg R.

BMC Health Services Research

Characterising Acute and Chronic Care Needs: Insights from the Global Burden of Disease Study 2019

GBD 2019 Acute and Chronic Care Collaborators

Nature Communications

Handheld Point-of-Care Devices for Snakebite Coagulopathy: A Scoping Review

Abouyannis M, Marriott AE, Stars E, Kitchen DP, Kitchen S, Woods TAL, Kreuels B, Amuasi JH, Monteiro WM, Stienstra Y, Senthilkumaran S, Isbister GK, Lalloo DG, Ainsworth S, Casewell NR.

Thrombosis and Haemostasis

Evaluating the Test-Negative Design for COVID-19 Vaccine Effectiveness Using Randomized Trial Data: A Secondary Cross-Protocol Analysis of 5 Randomized Clinical Trials

Andrews LIB, Halloran ME, Neuzil KM, van der Laan L, Huang Y, Andriesen J, Patel M, Fisher LH, Janes H, Rouphael N, Walsh SR, Theodore DA, Tieu HV, Sobieszczyk M, El Sahly HM, Baden LR, Falsey AR, Campbell TB, Kelley CF, Healy CM, Immergluck L, Luft B, Hirsch I, de Bruyn G, Truyers C, Priddy F, Sumner KM, Flannery B, Follmann D, Gilbert PB; COVID-19 Prevention Network (CoVPN)

JAMA Network Open

Perceptions of Barriers and Facilitators for Cervical Cancer Screening from Women and Healthcare Workers in Ghana: Applying the Dynamic Sustainability Framework

Boamah Mensah AB, Konney TO, Adankwah E, Amuasi J, Nones M, Okyere J, Boadu KO, Eduah FME, Xiong S, Moon JR, Virnig B, Kulasingam S.

PLOS Glob Public Health.

Incidence of Typhoid Fever in Burkina Faso, Democratic Republic of The Congo, Ethiopia, Ghana, Madagascar, And Nigeria (The Severe Typhoid in Africa Programme): A Population-Based Study

Marks F, Im J, Park SE, Pak GD, Jeon HJ, Wandji Nana LR, Phoba MF, Mbuyi-Kalonji L, Mogeni OD, Yeshitela B, Panzner U, Cruz Espinoza LM, Beyene T, Owusu-Ansah M, Twumasi-Ankrah S, Yeshambaw M, Alemu A, Adewusi OJ, Adekanmbi O, Higginson E, Adepoju A, Agbi S, Cakpo EG, Ogunleye VO, Tunda GN, Akihiko OO, Mbuyamba J, Toy T, Agyapong FO, Osei I, Amuasi J, …Owusu-Dabo E, Rakotozandrindrainy R.

Lancet Global Health

Improving The Clinical Trial Environment And Infrastructure: Moving From Global Resolution To Action

Moorthy V, Siegfried N, Amuasi J, Li J, Makanga M, Soares-Weiser K, Sivasampu S, Xavier D, Zannad F, Snewin V. Lancet Glob Health

Lancet Global Health

Correction: Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study

Wagstaff D, Amuasi J, Arfin S, Aryal D, Nor MBM, Bonney J, Dondorp A, Dongelmans D, Dullawe L, Fazla F, Ghose A, Hanciles E, Haniffa R, Hashmi M, Smith AH, Kumar B, Minh YL, Moonesinghe R, Pisani L, Sendagire C, Hasan MS, Ghalib MS, Frimpong MS, Ranzani O, Sultan M, Thomson D, Tripathy S, Thwaites L, Uddin RAME, Mazlan MZ, Waweru-Siika W, Beane A

Implementation Science

Mutations in Ace2 Gene Modulate Cytokine Levels and Alter Immune Responses in Mycobacterium Tuberculosis and SARS-Cov-2 Co-Infection: A Cameroonian Cohort.

Kameni MN, Tchoupe EB, Kamdem SD, Bhalla N, Assam Assam JP, Tepa AN, Neba FR, Nanda RK, Awuah AA, Amuasi JH, Netongo PM

Frontiers in Immunology

Risk Prediction Models to Determine Maternal and Newborn Adverse Pregnancy Outcomes in Low And Middle-Income Countries: A Scoping Review Protocol.

Opoku DA, Agyei-Baffour P, Gyaase S, Odei-Lartey E, Osarfo J, Gmanyami J, Appiah F, Adjei G, Enuameh Y.

PLoS One

Health Economics of Snakebite Envenomation: A Sub-Saharan African Perspective

Ayesiga I, Gmanyami JM, Akaka A, Kubwimana O, Ternor JN, Hashim UM, Gyabaah GA, Turzin JK, Kahwa I.

Transactions of The Royal Society of Tropical Medicine and Hygiene

Global emergency medicine: A scoping review of the literature from 2023

Hexom BJ, Quao NSA, Bandolin NS, Bonney J, Broccoli MC, Collier A, Dawson-Amoah NA, Dyal J, Kampalath V, Lee JA, Rees CA, de Oliveira Salvador GL, Strong JM, Kivlehan SM;Global Emergency Medicine Literature Review (GEMLR) Group

Academic Emergency Medicine

The African Critical Illness Outcomes Study (ACIOS): A point prevalence study of critical illness in 22 nations in Africa

Baker, Tim, Bonney J et al.

Lancet

Epidemiological and Clinical Features of Mpox During the Clade Ib Outbreak in South Kivu, Democratic Republic of the Congo: A Prospective Cohort Study

Brosius I, Vakaniaki EH, Mukari G, Munganga P, Tshomba JC, De Vos E, Bangwen E, Mujula Y, Tsoumanis A, Van Dijck C, Alengo A, Mutimbwa-Mambo L, Kumbana FM, Munga JB, Mambo DM, Zangilwa JW, Kitwanda SB, Houben S, Hoff NA, Makangara-Cigolo JC, Kinganda-Lusamaki E, Peeters M, Rimoin AW, Kindrachuk J, Low N, Katoto PDMC, Malembaka EB, Amuasi JH, Tshiani-Mbaya O, Kambaji DM, Kojan R, Kacita C, Mukadi-Bamuleka D, Ahuka-Mundeke S, Vercauteren K, Wawina-Bokalanga T, Muyembe-Tamfum JJ, Nundu SS, Liesenborghs L, Mbala-Kingebeni P.

Lancet

Completeness of Tuberculosis Case Notification in Ghana: Record Linkage and Capture-Recapture Analysis of Three TB Registries

Kwabla MP, Amuasi JH, Krause G, Dormechele W, Takramah W, Kye-Duodu G, Osei E, Der J, Baiden F, Adusi-Poku Y, Binka FN, Castell S.

BMC Infectious Diseases

Evidence based QUality Improvement for Prescribing Stewardship in ICU (EQUIPS-ICU): protocol for type III hybrid implementation-effectiveness study

Wagstaff D, Amuasi J, Arfin S, Aryal D, Nor MBM, Bonney J, Dondorp A, Dongelmans D, Dullawe L, Fazla F, Ghose A, Hanciles E, Haniffa R, Hashmi M, Smith AH, Kumar B, Minh YL, Moonesinghe R, Pisani L, Sendagire C, Hasan MS, Ghalib MS, Frimpong MS, Ranzani O, Sultan M, Thomson D, Tripathy S, Thwaites L, Uddin RAME, Mazlan MZ, Waweru-Siika W, Beane A

Implementation Science

Evaluating Tuberculosis Awareness and Screening Outcomes among Household Contacts of Index Cases: A Cross-Sectional Study in Ghana

Larbi-Debrah, P., Gmanyami, J. M., Andoono, A., Nsiah, R. B., Nyarko, D., Atsu-Ofori, O., Ayambire, G. A., Kyei, S., Morrison, I., Ayirebi, I., Obeng, L. N. A., Yusif, K. A., Nyarko, E., Mensah, I. O., Zakaria, S. A.-R., Badiekang, S. M., Yeboah, A. K., & Prempeh

Journal of Innovative Research

Characterizing Dengue Seroprevalence and Heterogeneities in Transmission Intensity in Ghana

Awuah, A., Vico, A., Adu, E.A., Boham, E.E., Alani, H., Wiredu, A.P., Adu-Amoah, L., Pedrique, B., Guillerm, M., Obirikorang, C. and Struck, N.S.

International Journal of Infectious Diseases

Combined Effect of the Timing of Initiation of Nutrition and Nutrition Risk on Outcomes in a Mixed Intensive Care Unit of a Tertiary Hospital in a Middle-income Country

Siaw-Frimpong M, Korula PJ, Karuppusami R, Gyapon NF, Subramani K, Chander RU, Rao S, Addison W.

Indian Journal of Critical Care Medicine

Assessing the Prevalence and Factors Influencing Male Involvement in Family Planning Services in an Urban Ghanaian Community

Ayirebi, I., Mabou, G. T., Nsiah, R. B., Gmanyami, J. M., Kyei, S., Charlotte, Y. D., Sosu, P., Sekyere, E. O., Morrison, M., Obeng, L. N. A., Nyarko, D., Agyeman-Duah, Y., Peprah, F. O., Nyarko, E., Atsu-Ofori, O., Prempeh, F., & Yeboah, A. K.

Journal of Innovative Research

2024

369 Adaptivity and (In)equity in a Crisis: Health System Resource Allocation During the COVID-19 Response in African Emergency Care

McCuskee S, Baah B, Bonney J, King LL, Owusu HO, Goldfrank L, Stassen W.

Annals of Emergency Medicine

Governance and Legal Considerations Supporting Prehospital Emergency Care in Low and Middle-Income Countries-For the Special Series on Prehospital Care In LMICs

Burkholder TW, Osei-Ampofo M, Bonney J.

Surgery

Protocol for a Mixed-Methods Study to Explore Implementation Outcomes of the Phone-Based Interventions Under Nurse Guidance After Stroke (PINGS-II) Across 10 Hospitals in Ghana.

Amuasi J, Agbogbatey MK, Sarfo F, Beyuo A, Agasiya P, Adobasom-Anane A, Newton S, Ovbiagele B.

BMJ Open

Exess mortality during the COVID-19 pandemic in low-and lower-middle-income countries: a systematic review and meta-analysis.

Gmanyami JM, Quentin W, Lambert O, Jarynowski A, Belik V, Amuasi JH.

BMC Public Health

Excess Mortality During the COVID-19 Pandemic in Low-and Lower-Middle-Income Countries: A Systematic Review and Meta-Analysis

Gmanyami JM, Quentin W, Lambert O, Jarynowski A, Belik V, Amuasi JH.

BMC Public Health

Malaria and other infections induce polyreactive antibodies that impact SARS-CoV-2 seropositivity estimations in endemic settings.

Aguilar R, Jiménez A, Santano R, Vidal M, Maiga-Ascofare O, Strauss R, Bonney J, Agbogbatey M, Goovaerts O, Boham EEA, Adu EA, Cuamba I, Ramírez-Morros A, Dutta S, Angov E, Zhan B, Izquierdo L, Santamaria P, Mayor A, Gascón J, Ruiz-Comellas A, Molinos-Albert LM, Amuasi JH, Awuah AA, Adriaensen W, Dobaño C, Moncunill G.

Journal of Medical Virology

Factors Associated with Skilled Birth Attendance in 37 Low-Income and Middle-Income Countries: A Secondary Analysis of Nationally Representative, Individual-Level Data

Priebe J, Amuasi J, Dartanto T, Mombo-Ngoma G, Guigas M. Lancet Glob Health

Lancet Global Health

Global, Regional, and National Incidence and Mortality Burden of Non-COVID-19 Lower Respiratory Infections and Aetiologies, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021

Bender RG, Sirota SB, Swetschinski LR, Dominguez RMV, Novotney A, Wool EE, Ikuta KS, Vongpradith A, Rogowski ELB, Doxey M, Troeger CE, Albertson SB, Ma J, He J, Maass KL, A.F.Simões E, Abdoun M, Aziz JMA, Abdulah DM, … Amuasi J, … Kyu HH.

Lancet Infectious Diseases

Prevalence and Risk Factors of Obesity among Undergraduate Student Population in Ghana: An Evaluation Study of Body Composition Indices

Obirikorang C, Adu EA, Anto EO, Afum-Adjei Awuah A, Fynn ANB, Osei-Somuah G, Ansong PN, Boakye AO, Ofori-Boadu I, Obirikorang Y, Adobasom-Anane AG, Nyarko EN, Balmer L.

BMC Public Health

Editorial: Vaccines and Immunization Services During the Pandemic Era and Beyond.

Amponsah-Dacosta E, Fulurija A, Afum-Adjei Awuah A, Mathema S, Wariri O.

Frontiers in Health Services

Immunomodulatory Therapy in Children With Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-Cov-2 (PIMS-TS, MIS-C; RECOVERY): A Randomised, Controlled, Open-Label, Platform Trial

Faust SN, Haynes R, Jones CE, Staplin N, Whittaker E, Jaki T, Juszczak E, Spata E, Wan M, Bamford A, Dimitri P, Finn A, Furness J, Ramanan AV, Gale C, Cathie K, Drysdale S, Bernatoniene J, Murray C, … Amuasi J, … Zuriaga-Alvaro A.

The Lancet Child & Adolescent Health

Clinical Epidemiology, Determinants, and Outcomes of Viral Encephalitis In Ghana: A Cross-Sectional Study

Yeboah R, Gorman R, Acheampong HK, Nyarko-Afriyie E, Aryeetey S, Tetteh HD, Owusu M, Yeboah ES, Adade T, Bonney J, Amoako YA, El-Duah P, Obiri-Danso K, Drosten C, Phillips RO, Sylverken AA

PLoS One

Draft of WHO Pandemic Agreement Plays Down Primary Prevention.

Alders R, Amuasi JH, Ashraf S, Becker D, Bukachi SA, Burza S, Cleveland S, El Omrani O, Erondu NA, Ferreira JM, Hassan L…. Mettenleiter TC, Winkler AS

Lancet

Global Emergency Medicine: A Scoping Review of the Literature from 2022

Hexom BJ, Quao NSA, Bandolin NS, Bonney J, Collier A, Dyal J, Lee JA, Nicholson BD, Rybarczyk MM, Rees CA, Roy CM, Bhaskar N, Kivlehan SM; Global Emergency Medicine Literature Review (GEMLR) Group.

Academic Emergency Medicine

2023

The Burden of Bacterial Antimicrobial Resistance in The WHO African Region in 2019: A Cross-Country Systematic Analysis

Benn Sartorius, Authia P Gray, Nicole Davis Weaver, Gisela Robles Aguilar, Lucien R Swetschinski, Kevin S Ikuta, Tomislav Mestrovic, Erin Chung, Eve E Wool, …John H Amuasi… Christopher J L Murray, Mohsen Naghavi.

Lancet Global Health

Mhealth Tools for Community-Based Infectious Disease Surveillance in Africa: A Scoping Review Protocol

Aku FY, Amuasi JH, Debrah LB, Opoku D, Gmanyami JM, Hoerauf A, Debrah AY, Quentin W.

BMJ Open

Stakeholder Perspectives from 15 Countries in Africa on Barriers in Snakebite Envenoming Research and the Potential Role of Research Hubs

Stienstra Y, Aglanu LM, Schurer JM, Mijumbi R, Mbonigaba JB, Habib AG, Thomas B, Steinhorst J, Thomson R, Padidar S, Amuasi JH, Oluoch GO, Lalloo DG.

PLOS Neglected Tropical Diseases

A Simulation-Based Method to Inform Serosurvey Design for Estimating the Force of Infection Using Existing Blood Samples

Vicco A, McCormack CP, Pedrique B, Amuasi JH, Awuah AA, Obirikorang C, Struck NS, Lorenz E, May J, Ribeiro I, Malavige GN, Donnelly CA, Dorigatti I.

PLOS Computational Biology

Integrated Emergency, Critical, and Operative Care: A Coordinated Approach to Strengthening Emergency Care and Health Service Delivery

Tupesis JP, Bonney J, Connolly J, Howlett MK, Kang C, Convocar P, Lai King L, Skinner C, López Tapia D, Davies F.

Academic Emergency Medicine

Mixed Methods Study Protocol for Combining Stakeholder-Led Rapid Evaluation with Near Real-Time Continuous Registry Data to Facilitate Evaluations of Quality of Care in Intensive Care Units

Collaboration for Research, Implementation and Training in Critical Care in Asia and Africa (CCAA); Rashan A, Beane A, Ghose A, Dondorp AM, Kwizera A, Vijayaraghavan BKT, Biccard B, Righy C, Thwaites CL, Pell C, Sendagire C, Thomson D, Done DG, Aryal D, Wagstaff D, Nadia F, Putoto G, Panaru H, Udayanga I, Amuasi J, Salluh J, Gokhale K, Nirantharakumar K, Pisani L, Hashmi M, Schultz M, Ghalib MS, Mukaka M, Mat-Nor MB, Siaw-Frimpong M, Surenthirakumaran R, Haniffa R, Kaddu RP, Pereira SP, Murthy S, Harris S, Moonesinghe SR, Vengadasalam S, Tripathy S, Gooden TE, Tolppa T, Pari V, Waweru-Siika W, Minh YL

Wellcome Open Research

Efficacy of a Bivalent (D614 + B.1.351) SARS-Cov-2 Recombinant Protein Vaccine with AS03 Adjuvant in Adults: A Phase 3, Parallel, Randomised, Modified Double-Blind, Placebo-Controlled Trial

Dayan GH, Rouphael N, Walsh SR, Chen A, Grunenberg N, Allen M, Antony J, Asante KP, Bhate AS, Beresnev T, Bonaparte MI, Celle M, Ceregido MA, Corey L, Dobrianskyi D, Fu B, Grillet MH, Keshtkar-Jahromi M, Juraska M, Kee JJ, Kibuuka H, Koutsoukos M, Masotti R, Michael NL, Neuzil KM, Reynales H, Robb ML, Villagómez Martínez SM, Sawe F, Schuerman L, Tong T, Treanor J, Wartel TA, Diazgranados CA, Chicz RM, Gurunathan S, Savarino S, Sridhar S; VAT00008 Study Team

Lancet Respiratory Medicine

Impact of COVID-19 on Health Service Utilisation in Sub-Saharan Africa: Protocol for a Scoping Review

Tannor EK, Quentin W, Busse R, Opoku D, Amuasi J.

BMJ Open

Efficacy of a Monovalent (D614) SARS-Cov-2 Recombinant Protein Vaccine with AS03 Adjuvant in Adults: A Phase 3, Multi-Country Study

Dayan GH, Rouphael N, Walsh SR, Chen A, Grunenberg N, Allen M, Antony J, Bhate AS, Beresnev T, Bonaparte MI, Celle M, Ceregido MA, Corey L, Fu B, Grillet MH, Keshtkar-Jahromi M, Juraska M, Kee JJ, Kaali S, Koutsoukos M, Masotti R, Michael NL, Neuzil KM, Reynales H, Robb ML, Uchiyama A, Sawe F, Schuerman L, Shrestha R, Tong T, Treanor J, Diazgranados CA, Chicz RM, Gurunathan S, Savarino S, Sridhar S; VAT00008 study team

EClinicalMedicine

Community Members and Healthcare Workers’ Priorities for the Control and Prevention of Snakebite Envenoming in Ghana

Aglanu LM, Amuasi JH, Prokesh E, Beyuo A, Dari CD, Ravensbergen SJ, Agbogbatey MK, Adobasom-Anane AG, Abass KM, Lalloo DG, Blessmann J, Kreuels B, Stienstra Y.

PLOS Neglected Tropical Diseases

How Funders Can Support Improved Clinical Trial Practice for Outbreaks

Foster I, Amuasi J, Geelen J, Miyagawa S, Böcking D, Hagen H, Sigfrid L, Norton A; GloPID-R Clinical Trial Networks and Funders Working Group

Lancet

Higher Dose Corticosteroids in Patients Admitted to Hospital With COVID-19 Who Are Hypoxic But Not Requiring Ventilatory Support (RECOVERY): A Randomised, Controlled, Open-Label, Platform Trial

RECOVERY Collaborative Group

Lancet

Evaluation of Four Malaria Rapid Diagnostic Test Kits Used at the Enyiresi Government Hospital in the Eastern Region of Ghana

Seth A. Domfeh, Boateng Y. Darkwa, Raymond K. Gablah, Evans Adu-Asamoah, Christian Obirikorang

Journal of Parasitology Research

The Person-To-Person Transmission Landscape of The Gut and Oral Microbiomes

Valles-Colomer M, Blanco-Míguez A, Manghi P, Asnicar F, Dubois L, Golzato D, Armanini F, Cumbo F, Huang KD, Manara S, Masetti G, Pinto F, Piperni E, Punčochář M, Ricci L, Zolfo M, Farrant O, Goncalves A, Selma-Royo M, Binetti AG, Becerra JE, Han B, Lusingu J, Amuasi J, Amoroso L, Visconti A, Steves CM, Falchi M, Filosi M, Tett A, Last A, Xu Q, Qin N, Qin H, May J, Eibach D, Corrias MV, Ponzoni M, Pasolli E, Spector TD, Domenici E, Collado MC, Segata N.

Nature

Correspondence: The African Snakebite Alliance

Oluoch GO, Stienstra Y, Schurer JM, Mijumbi R, Mbonigaba JB, Thomas B, Padidar S, Amuasi J, Lalloo DG.

Toxicon

2022

What the snake leaves in its wake: Functional limitations and disabilities among snakebite victims in Ghanaian communities

Aglanu LM, Amuasi JH, Schut BA, Steinhorst J, Beyuo A, Dari CD, Agbogbatey MK, Blankson ES, Punguyire D, Lalloo DG, Blessmann J, Abass KM, Harrison RA, Stienstra Y.

PLOS Neglected Tropical Diseases

2018

Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients

Harling K, Adankwah E, Güler A, Afum-Adjei Awuah A, Adu-Amoah L, Mayatepek E, Owusu-Dabo E, Nausch N, Jacobsen M

Cellular & molecular immunology. 2019 Mar;16(3):275-287. doi: 10.1038/cmi.2018.5

Neglected tropical diseases – the present and the future

Winkler AS, Klohe K, Schmidt V, Haavardsson I, Abraham A, Prodjinotho UF, Ngowi B, Sikasunge C, Noormahomed E, Amuasi J, Kaducu J, Ngowi H, Abele-Ridder B, Harrison WE, Prazeres da Costa C

Tidsskrift for Den Norske Legeforening. 2018 Jan 2;138(3):10.4045/tidsskr.17.0678. doi: 10.4045/tidsskr.17.0678

Powering up Sub-Sahara Africa’s renewable energy revolution through diffusion

Aglanu LM

International Journal of Development and Sustainability 7(2): 685-700

2017

Conducting an Enterprise Architecture Impact Study (EAIS) for Recommendations of Developing and Implementing Health Registries to Improve Data Collection and Public Health Surveillance

Wright MM

Emory University Electronic and Thesis and Dissertation Library 2017

Missed opportunities for the diagnosis of Brucella infection among slaughterhouse workers at the Kumasi Abattoir, Ghana

Amegashie EA, Annan, AA, Awuah AAA, Larbi R, Addofoh N, Feglo PK, & Owusu-Dabo E

Journal of Epidemiological Research. 2017 3(2):58. doi:10.5430/jer.v3n2p58, 3(2), 58

Current meningitis outbreak in Ghana: Historical perspectives and the importance of diagnostics

Kwarteng A, Amuasi J, Annan A, Ahuno S, Opare D, Nagel M, Vinnemeier C, May J, Owusu-Dabo E

Acta Tropica. 2017 May;169:51-56. doi: 10.1016/j.actatropica.2017.01.014

Systemic inflammatory response syndrome and model for end-stage liver disease score accurately predict the in-hospital mortality of black African patients with decompensated cirrhosis at initial hospitalization: a retrospective cohort study

Mahassadi AK, Nguieguia JLK, Kissi HY, Awuah AA, Bangoura AD, Doffou SA, Attia AK

Clinical and experimental gastroenterology. 2018 Apr 9:11:143-152. doi: 10.2147/CEG.S140655

Improving estimation of ACT treatment coverage in Africa

Amuasi JH

The Lancet Global Health. 2017 Apr;5(4):e375-e376. doi: 10.1016/S2214-109X(17)30087-6

Post-licensure safety evaluation of dihydroartemisinin piperaquine in the three major ecological zones across Ghana

Oduro AR, Owusu-Agyei S, Gyapong M, Osei I, Adjei A, Yawson A, Sobe E, Baiden R, Adjuik M, Binka F

PLoS One. 2017 Mar 30;12(3):e0174503. doi: 10.1371/journal.pone.0174503

Pseudomonas oryzihabitans sepsis in a 1-year-old child with multiple skin rashes: a case report

Owusu M, Owusu-Dabo E, Acheampong G, Osei I, Amuasi J, Sarpong N, Annan A, Chiang HY, Kuo CH, Park SE, Marks F, Adu-Sarkodie Y

Journal of Medical Case Reports. 2017 Mar 23;11(1):77. doi: 10.1186/s13256-017-1230-6.

Alternative Quantiferon cytokines for diagnosis of children with active tuberculosis and HIV co-infection in Ghana

Lundtoft C, Awuah AA, Nausch N, Enimil A, Mayatepek E, Owusu-Dabo E, Jacobsen M

Medical microbiology and immunology. 2017 Jun;206(3):259-265. doi: 10.1007/s00430-017-0501-6

KCCR-based

  • Prof. John H. Amuasi (Group Leader)
  • Prof. Christian Obirikorang (Senior Research Fellow)
  • Dr. Ama Amuasi (Senior Research Fellow)
  • Dr. Rose Odotei-Adjei (Senior Research Fellow)
  • Bernice Benewaa Asare (Administrative Assistant)
  • Kwabena Appiah Boahen (Logistician)
  • Vitus Kudimaya (Driver)
  • Owusu Sarfo Addai (Driver)
  • Sarfo Agyapong Kese (Driver)
  • Eric Ebenezer Boham (PhD student)
  • Evans Asamoah Adu (PhD student)
  • Austin Gideon Adobasom Anane (PhD student)
  • Robert Asampong (Lead Statistician, PhD Student)
  • Anita Eshun (Data Scientist)
  • Dr. Neta Parsram (Study Doctor, Communications Lead)
  • Dr. Beatrice Okrah (Study Doctor)
  • Dr. Akosua Owusu Bempomaa (Study Doctor)
  • Dr. Andrew Nii Ashon Bruce (Study Doctor)
  • Charlotte Adu- Tweneboah (Senior Research Assistant)
  • Alexander Owusu Boakye (Senior Research Assistant)
  • Senam Yawa Nunamey Ahadzie (Senior Research Assistant)
  • James Deke (Senior Research Assistant, PhD Student)
  • Maxwell Nsoh (Quality Assurance Officer)
  • Sylvester Newton (Senior Research Assistant)
  • Hakim Alani (Masters Student)
  • Charles Tengan (Senior Research Assistant)
  • Lily Pokuaa Asare (Senior Research Assistant)
  • Louisa Domfe (Masters Student)
  • Emmanuel Akakpo (Masters Student)
  • Esther Baker (Research Assistant)
  • Louis Adu-Amoah (Research Fellow, PhD Student)
  • Leslie Mawuli Aglanu (Research Fellow, PhD Student)
  • Ramatu Abdul Hamid Alhassan (Project Manager)
  • Deborah Somuah (Finance Officer)
  • Jonathan Gmanyami (Field Supervisor, PhD Student)
  • Joseph Frimpong Boahene (Research Assistant, Masters Student)
  • Patrick Agasiya (Masters Student)
  • Stephanie Donkor (Research Assistant)
  • Gyasi Darko Jnr (Research Assistant)
  • Jessica Edinam Bludor (Research Assistant)
  • Audrey Eyram Agbeve (Research Assistant)
  • Lawrence Antwi-Yeboah (Research Assistant)

 

KATH-based

  • Dr. Moses Siaw-Frimpong (Study Doctor, Research Fellow)
  • Leeward-Amissah Esi (Research Assistant)
  • Frank Arhin Donkor (Research Assistant)
  • Firdaws Sadick (Research Assistant)
  • Lawrence Addai-Boampong (Pharmacy Technician)
  • Gertrude Ahenewaa Gyabaah (Senior Research Assistant)
  • Juliana Akua Antwiwaa (Research Assistant)
  • Eudora Obeng Sackey (Physician Assistant)
  • Stephen Bredu (Research Assistant)

 

KNUST-based

  • Prof. Sam Kofi Newton (Ethics Lead and Clinical Advisor)
  • Dr. Daniel Opoku (Senior Research Fellow)

 

CAPE COAST-based

  • Edward Atsu (Research Assistant)
Group Leader

John H. Amuasi
Phone: +233 3220 60351
E-Mail: amuasi@kccr.de

Senior Research Fellow

Christian Obirikorang
E-Mail: 

Deputy Group Lead

Anthony Afum Adjei-Awuah
E-Mail: afumadjeiawuah@kccr.de

Clinical Lead

Joseph Bonney 
E-Mail: j.bonney@kccr.de

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