Filariases (ALEX DEBRAH GROUP)

Head

Dr. Alexander Yaw Debrah,
Faculty of Allied Health Sciences,
Kwame Nkrumah University of Science and Technology
Kumasi
Tel: +233(0)209341317
Fax.: +233(0)322062017

Staff

  1. Dr. Mrs. Linda Batsa Debrah (PhD[Coordinator of filariasis projects]
  2. Dr. Nana Kwame Ayisi-Boateng (MD)
  3. Dr. Peter Konadu (Surgeon)
  4. Dr. Henry Attawura (Urologist)
  5. Dr. Charles Kokor (MD)
  6. Dr. Frederick Oduro (MD)
  7. Dr. Juliet Yirerong (MD)
  8. Dr. Solomon Nii-Kotey Kotey (MD)
  9. Yusif Mubarik (BSc)
  10. Collins Amanfo (BSc)

 Graduate students

  1. Alexander Kwarteng (PhD student)
  2. Jubin Osei-Mensah (PhD student)
  3. Daniel Antwi-Berko (PhD student)
  4. Charles Badiwon (M’Phil)
  5. Theodora Lamptey (M’Phil student)

Project descriptions

– Death to Onchocerciasis and Lymphatic Filariasis (DOLF)

The objective of this study is to determine if repeated doses of ivermectin combined with albendazole given annually or semiannually is better than ivermectin alone given annually or semiannually for treatment of patients with filarial infections (Onchocerca volvulus) as measured by higher sterility of adult female worms and reduction in skin microfilaria.

Funded by: Bill and Melinda Gates Foundation

External collaborators:

  • Prof. Achim Hoerauf of Institute of Microbiology, Immunology and Parasitology (IMMIP), University of Bonn
  •  Prof. Christopher King of Center for Global Health & Diseases, Case Western Reserve University (USA).
  • Prof. James Kazura of Center for Global Health & Diseases, Case Western Reserve University (USA).

Analysis of genetic polymorphisms of cytokines, vascular endothelial growth factors (VEGFs) and VEGF receptors in disease manifestations in lymphatic filariasis (NTD-Genetics)

This project aims at analyzing pro- and anti-inflammatory cytokine, VEGF and VEGF receptor polymorphisms and other lymphangiogenic/angiogenic molecules as possible causes of the different disease manifestations in patients with lymphatic filariasis, especially elucidating the underlying factors responsible for patency/latency in lymphatic filariasis.

Funded by: The European Foundations Initiative for African Research into Neglected Tropical Diseases (EFINTD)

External collaborators

  • Prof. Achim Hoerauf and Dr. Kenneth Pfarr of Institute of Microbiology, Immunology and Parasitology (IMMIP), University of Bonn
  • Prof. Bernard Fleischer of Bernard Nocht Institute of Hamburg.

– Genetics of Lymphoedema and Hydrocele in Filariasis (DFG-genetics)

The aim of this study is to elucidate lymphatic filariasis pathology biomarkers with a focus on lymphangiogenic/angiogenesis single nucleotide polymorphisms in lymphoedema, hydrocele and infected patients as possible causes of the different disease manifestations in patients with lymphatic filariasis.

Funded by: German Research Foundation (DFG)

External collaborators:
• Prof. Achim Hoerauf and Dr. Kenneth Pfarr of Institute of Microbiology, Immunology and Parasitology (IMMIP), University of Bonn.


– Anti-symbiotic treatment of filariasis (AWOL)

The aim is to refine existing regimes of drugs with known activity against Wolbachia and to provide an optimized treatment regime in the event of the development of resistance or poor responsiveness which can be integrated in the MDA timeframes of the existing control programmes for lymphatic filariasis and onchocerciasis.

Funded by: Bill and Melinda Gates Foundation

External collaborators:
• Prof. Mark Taylor of Liverpool School of Tropical Medicine
• Prof. Achim Hoerauf Institute of Microbiology, Immunology and Parasitology (IMMIP), University of Bonn.

Pictures


– Enhanced Protective Immunity Against Filariasis (EPIAF)
Funded by: The European Commission

External collaborators
• Prof. David Taylor of University of Edinburgh
• Prof. Achim Hoerauf of Institute of Microbiology, Immunology and Parasitology (IMMIP), University of Bonn.

Pictures


– CAnti-wolbachial therapy with doxycycline to ameliorate filaricele pathology (VW- filariasis)
Funded by: Volkswagen (VW) Foundation of Germany

External collaborators:
• Prof. Achim Hoerauf and Dr. Sabine Mand Institute of Microbiology, Immunology and Parasitology (IMMIP), University of Bonn.

Pictures


– Sustainable Control of Onchocerciasis Today and Tomorrow (SCOOTT)

The aim of this study is to assess the effect of doxycycline on individual onchocerciasis patients in whom repeated ivermectin treatment has failed to mediate microfilariae clearance.

Funded by: The European Commission

External collaborators
• Prof. David Taylor of University of Edinburgh
• Prof. Achim Hoerauf of Institute of Microbiology, Immunology and Parasitology (IMMIP), University of Bonn.

Pictures


– Lymphatic filariasis morbidity management: Case identification and monitoring using volunteer community health workers

The aim of this study is to assess whether community health workers (CHWs) are able to effectively report and monitor lymphatic filariasis morbidity cases using an SMS-based morbidity surveillance tool.

Funded by: Liverpool School of Tropical Medicine

External collaborators
• Dr. Michelle Stanton and Dr. Louise Kelly-Hope of Liverpool School of Tropical Medicine
• Nana-Kwadwo Biritwum of Ghana Health Service.

Kumasi Center for Collaborative Research in Tropical Medicine