Category Archives: Uncategorized

Introduction to Clinical Research and Development

 Kumasi Centre for Collaborative Research (KCCR),

Introduction to Clinical Research and Development

Course date: May 15- 26, 2017

Venue: KCCR Seminar Room


Course Overview

This course is an intensive, two-week, full-time (09.00 hours to 17.00 hours, Monday-Friday) course in Clinical Research and Development for health-related workers. It covers the basic concepts of clinical research and provides an introductory overview aimed at everyone involved in clinical research and focuses on the main areas of why and how clinical research is carried out and the importance of ethics in research.

It shall combine practical case studies series of lectures and seminars designed to equip participants with the practical and contextual knowledge of implementing clinical trials.

Faculty on the course, most of whom have extensive years of research in clinical research will come from Ghana and South Africa. The course will provide the setting for hands-on case studies and interaction with faculty as well as cutting edge didactic teaching.

Aims of the Course

The course aims to teach participants in the health profession the skills required to understand and undertake clinical studies. It is intended to introduce participants to the design, conduct and management of clinical studies with special emphasis on Research ethics, pharmacovigilance and Good clinical practice among others

Course outline

Much of the course time will be devoted to lectures and seminars, during which a multi-disciplinary team of experts will cover thematic modules in great detail. Lectures will cover the following areas:

  • Research ethics
  • Study design
  • Study protocol
  • ICH-GCP
  • GCLP
  • Informed consent
  • Collecting and Reporting Adverse Events
  • Pharmacovigilance
  • Data management in clinical research
  • Children and Clinical Research
  • Trial design and management
  • Conducting GCP Inspections/Audits at the Clinical Investigator Site
  • Conducting trials in resource limited setting (Africa)
  • Community engagement in research implementation
  • Intellectual property management.

Time will be set aside after each lecture for discussions and case studies that will allow participants to put to direct use what they have studied. Additionally, lectures will be followed by interactive sessions with faculty to allow participants the opportunity to follow up on lectures that time could not permit complete exhaustion of content. It would also allow faculty to get to know course participants and share personal experiences in relevant modules that could not have been discussed during the scheduled period. Time will also be set aside during the course period for networking

Course fee/Scholarships (does not include air fares)

This course is being organized with sponsorship from WHO-TDR. Therefore, participants shall be selected on the basis of full funding under the auspices of the funder. This covers course tuition, course materials and feeding but does NOT include accommodation.

 

Who should apply for the course?

The course is open to early career research scientists and staff in the field of clinical and biomedical research. This includes postgraduate students, laboratory technologists and technicians, Post-docs, Medical Doctors, Nurses, District health directors, Health program managers and lecturers.

Applicants must have a good standard of written and spoken English.

Accommodation

This will be a daily course held from 9.00-18.00 hours. Participants will be responsible for their accommodation arrangements.

How to apply

Please download the application form here, and include the following:

  • The completed application form,
  • One-page personal motivation statement of purpose (500 words),
  • A one-page letter explaining how the course will contribute to your career development (500 words)
  • Two (2) letters of recommendation

Send to:

 The Course Facilitator

(e-mail: afumadjeiawuah@kccr.de; Tel. no. +233 242 107 721)

 Deadline for application is Sunday 30th April 2017

 

 

 

 

CERTIFICATE COURSE IN TROPICAL MEDICINE

Certificate Course in Tropical Medicine, organized by the Kumasi Centre for Collaborative Research (KCCR), College of Health Sciences, KNUST, Kumasi, and the Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, Germany.

Course date: 21st Nov – 2nd Dec, 2016
Venue: KNUST, Kumasi, Ghana

Overview

The Certificate Course in Tropical Medicine (CCTM) is an intensive,
two-week, full-time course in Tropical Medicine for health-related workers.

It combines practical work, a series of lectures and seminars designed to equip potential attendees with the practical and factual knowledge of Tropical Medicine.

Faculty on the course, most of whom have lived and worked in the tropics will come from Ghana and Germany. The KCCR laboratories will provide the setting for hands-on laboratory work as well as cutting edge didactic teaching.

Aims of the Course

The course aims to teach people in the health profession the skills required to understand, diagnose, treat and prevent diseases that are especially prevalent in tropical and developing countries where resources may be limited. The course has a strong epidemiological base but the scientific basis of tropical infectious diseases will also be given priority.

Course outline

Much of the course will be devoted to lectures and seminars, during which a multi-disciplinary team of experts will cover a particular disease or group of diseases in depth. Lectures will cover the causative organisms, epidemiology, pathogenesis, clinical features, diagnosis, management and prevention of these diseases. Time will be set aside after each lecture for discussion.

Lectures will be followed by practical sessions during which the laboratory diagnosis of the major diseases will be taught. The course is intensive, without much free time during the two weeks and continues until 17.00 hours. However, weekends are free and a field trip has been planned for this year’s course.

Accreditation

The Academic Board of the Kwame Nkrumah University of Science and Technology has approved the curriculum of the CCTM.

Course fee/Scholarships (does not include air fares)

European countries – 1,500 Euros (Course fee, lodging and feeding)

African countries – 800 Euros (Course, lodging and feeding)

Ghanaian residents: 2000 New Ghana cedis (Course and feeding)

Who should apply for the course?

The CCTM course is open to workers in the medical field. This includes students (Post-grads), Epidemiologists, Research Scientists, Post-Docs, Medical Doctors, Clinical students, District health directors, etc.

Applicants must have a good standard of written and spoken English.

Accommodation

The CCTM will NOT provide residential accommodation, but a wide range of student accommodation is available on Campus. A number of University Halls of Residence provide accommodation. There are private hostels run by other organizations as well as many privately-rented lodgings, flats or houses.

How to apply

Please download the application form online, and send the completed application form, one-page motivation statement of purpose, a CV and two (2) letters of reference to:

The Course Facilitator
(e-mail: info@kccr.de; Tel. no. +233 32 2060351)

Deadline for application is Friday 11th November 2016

DELGEME CALL FOR MSC, PHD AND POST-DOCTORAL FELLOWSHIPS

DELGEME CALL FOR MSC, PHD AND POST-DOCTORAL FELLOWSHIPS

The Developing Excellence in Leadership and Genetics Training for Malaria Elimination in sub-Saharan Africa (DELGEME) programme is launching new calls for MSc, PhD, Post Docs to start in 2016

Background

The Developing Excellence in Leadership and Genetics Training for Malaria Elimination in sub-Saharan Africa (DELGEME) is a new training programme sponsored by the Wellcome Trust Developing Excellence in Leadership, Training and Science Africa (DELTAS Africa) initiative in partnership with the Department of International Development (DFID) and the Alliance for Accelerating Excellence in Science in Africa (AESA). The partner institutions are the University of Science Techniques and Technologies of Bamako Mali (USTTB), Medical Research Council (MRC) Unit in The Gambia, The United States Army Medical Research Directorate (USAMRD-K)/KEMRI Kenya, The Noguchi Memorial Institute for Medical Research (NMIMR)-Navrongo Health Research Centre, Ghana, The National Institute of Medical Research (NIMR) Tanzania, Université des Sciences de la Santé of Libreville, Gabon, Benhard-Nocht Institute for Tropical Medicine (BNITM) Germany/Kumasi Centre for Collaborative Research (KCCR) Ghana, and the University of Oxford/Wellcome Trust Sanger Institute UK.
It is led by USTTB with MRC and USAMRD-K/KEMRI as the training hubs. In collaboration with MalariaGEN (www.malariagen.net) and the Plasmodium Diversity Network Africa (PDNA, http://www.cggh.org/collaborations/plasmodium-diversity-network-africa), DELGEME aims to enrich the pool of African Scientists working in African institutions with relevant expertise to leverage big genetics and genomics data in the drive for malaria elimination in sub-Saharan Africa.
Over the next five years, DELGEME will be providing short-term and degree training (MSc, PhD, Post-doctoral) to at least 90 young African scientists. Fellowships will be hosted at an African institution with a curriculum in genetics, genomics, bioinformatics, biostatistics, data science and ethical issues in genetics/genomics. DELGEME fellows are expected to develop a research proposal that explore critical gaps in malaria genetics and molecular epidemiology to aid the malaria elimination agenda. Dedicated computational facilities will be available for fellows at the USTTB, the MRC, and USAMRD/KEMRI.

Objectives

To develop advanced technical and analytical skills of African scientists in relevant areas of bioinformatics, next generation sequence analysis, population genetics, epidemiology, statistical and cellular/molecular biology of parasites, hosts and vectors in collaboration with local and International partners for malaria control and elimination in sub-Saharan Africa.
The specific aims of this call are to invite applicants for MSc, PhD and Post-Doctoral training in the above fields.

Evaluation criteria

  1. The candidate’s qualifications and motivations;
  2. The research quality of the project (for PhDs and Post-docs);
  3. The relevance of the proposed project in relation to the objectives of the call for proposals (for PhDs and Post-Docs);
  4. The academic basis of the PhD or Post-doc project at the relevant University or partner Institution.

Who can apply?

Only candidates who are nationals of PDNA memberi countries are eligible to respond to this call. It is a prerequisite that applications and projects are prepared in collaboration with at least one PDNA member institutionii. Prospective candidate must enroll or be currently enrolled for MSc or PhD in an appropriate Graduate School within Africa. For PhDs and Post-Doctoral fellows, it must be clearly demonstrated in the application that the proposed project is affiliated with an active research environment at a University/Research Institution. Candidates with an undergraduate training in computational, mathematics and physical sciences are also encouraged to apply.

Financial framework

The grant for each MSc fellowship will be up to £26,000 for two years or £13,000 for candidates who have already completed 1 year in a related curriculum towards a MSc. PhD fellowship will be up to £63,000 for 3 years and Post-doctoral fellowship will be up to £120,000 for 3 years. This amount includes student’s stipend, research cost, and other training/research related costs. The final amount awarded will be determined at the time of award notification.

Application procedure:
Step 1
Candidates must provide the following supporting documentation as part of their application
1. A cover page including Personal informations:
a. Full names as they appear on applicant’s ID/passport;
b. Full contact details, including residential and postal address; email and telephone number(s); and
c. Name of institution at which the applicant wishes to undertake his/her training/degree (Master, PhD studies, Postdoctoral) study.
2. Letter of support from the prospective host PDNA Supervisor
3. A motivation letter (not longer than one A4 page – 500 words)
4. A research proposal outlining the problem statement, methodology, feasibility of the study and the contribution that it will make to the body of knowledge in the particular field of study (PhDs and Post-Doctoral Fellows only) (not longer than five A4 pages).
5. Two letters of recommendation from academic referees.
6. A certified copy of full academic transcript/s and certificates?
7. A copy of ID/passport
8. The most current CV (maximum 2 pages).

Step 2
The application must be submitted electronically to delgemecalls@delgeme.org and consists of the full application and the appendices. The appendices template and guidelines can be downloaded from the website www.delgeme.org

The deadline for applications is:
Sunday 30 September 2016 at 17:00GMT for MSc fellowships and
Tuesday 30 October 2016 at 17:00 GMT for PhDs and Post-Doctoral Fellows.
Applicants will receive an email to confirm receipt shortly after the application is received.

Contacts
For further information, please contact the DELGEME office:
Prof. Djibril Sangare
Programme Manager DELGEME
University of Science, Techniques and Technology of Bamako (USTTB) P.O. Box: 1805 Point G, Bamako; Mali (West Africa)
Phone: +223 75160745/ +223 99963095

iPlasmodium Diversity Network Africa, PDNA (http://www.cggh.org/collaborations/plasmodium-diversity-network-africa; (South Africa, Angola, Cameroon, Côte d’Ivoire, Cape Vert, Ethiopia, Gabon, Ghana, The Gambia, Kenya, Madagascar, Mali, Mozambique, RD Congo and Tanzania)
ii Abdoulaye Djimde (adjimde@icermali.org)/Malaria Research and Training Center – University of Science, Techniques and Technologies of Bamako, Mali; Milijaona Randrianarivelojosia (milijaon@pasteur.mg)/Institut Pasteur de Madagascar; Antoinette Tshefu-Kitoto (antotshe@yahoo.com) & Dieudonne Mumba (mumbadieudonne@yahoo.fr)/ University of Kinshasa; Paulina Tindana (ptindana@gmail.com)&Lucas Amenga-Etego (lucasmenga@gmail.com)/ Navrongo Health Research Center (NHRC); Lemu Golassa (lgolassa@gmail.com)/ Addis Ababa University, Ethiopia; Tobias Apinjoh (apinjoh.tobiasa@ubuea.cm)/ University of Buea; Yavo William (yavowilliam@yahoo.fr)/ University FHB of Abidjan – National Institute of Public Health, Côte d’Ivoire; Alfredo Mayor (alfredo.mayor@isglobal.org)/ Centro de Investigaçao em Saúde de Manhiça (CISM) and Barcelona Institue for Global Health (ISGlobal); Jaishree Raman (JaishreeR@nicd.ac.za) / National Institute for Communicable Diseases (NICD); Joana Alves/ Instituto Nacional de SaúdePública, Ministério da Saúde de Cabo Verde ; Maria Do Rosario Bragança Sambo (rosariosambo@hotmail.com) / Faculty of Medicine of KatyavalaBwila University; Alfred Amambua-Ngwa (angwa@mrc.gm)/Medical Research Council Unit The Gambia; Anita Ghansah (aghansah2013@gmail.com)/Noguchi Memorial Institute for Medical Research; Oumou Maiga-Ascofare (maiga@bni-hamburg.de) /Benhard-Nocht Institute for Tropical Medicine (BNITM) – Kumasi Centre for Collaborative Research (KCCR); Deusdedith Ishengoma (deusishe@yahoo.com)/National Institute for Medical Research; Marielle Bouyou-Akotet (mariellebouyou@yahoo.fr)/Université des Sciences de la Santé, Libreville; Maj Matthew Brown (Matthew.Brown@usamru-k.org), Ben Andagalu (ben.andagalu@usamru-k.org) & Edwin Kamau (edwin.kamau.mil@mail.mil)/ United states Army Research Directorate-Kenya

Publications 2016

1.     Frank C, Krumkamp R, Sarpong N, Sothmann P, Fobil JN, Foli G, Jaeger A, Ehlkes L, Owusu-Dabo E, Adu-Sarkodie Y, Marks F, Schumann RR, May J, Kreuels B. Spatial heterogeneity of malaria in Ghana: a cross-sectional study on the association between urbanicity and the acquisition of immunity. Malar J. 2016;15(1):84. doi: 10.1186/s12936-016-1138-4.

2. Sarkodie F, Owusu-Dabo E, Owusu-Ofori S, Bates I, Bygbjerg IC, Ansah JK, Ullum H. Syphilis screening practices in blood transfusion facilities in Ghana. International Journal of Infectious Diseases (2016); 43: 90-4. Doi:10.1016/j.ijid.2015.12.020

3. Sarkodie F, Ullum H, Owusu-Dabo E, Owusu-Ofori S, Owusu-Ofori A, Hassal O. A novel strategy for screening blood donors for syphilis at Komfo Anokye Teaching Hospital, Ghana. Transfusion Medicine. 2016. Doi: 10.1111/tme.12279.

4. Danquah DA, Buabeng KO, Asante KP, Mahama E, Bart-Plange C, Owusu-Dabo E. Malaria case detection using rapid diagnostic test at the community level in Ghana: consumer perception and practitioners’ experiences. Malar J. 2016; 15 (1): 34.doi: 10.1186/s12936-016-1086-z

5.     Addai-Mensah O, Seidel M, Amidu N, Maskus DJ, Kapelski S, Breuer G, Franken C, Owusu-Dabo E, Frempong M, Rakotozandrindrainy R, Schinkel H, Reimann A, Klockenbring T, Barth Stefan, Fishcer Rainer, Fendel R. Acquired immune response to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria. Malar J. 2016, 15 (1): 65. Doi:10.1186/s12936-016-1112-1
6. Yar, D.D., Salifu, S.P., Darko, S.N., Annan, A.A., Gyimah, A.A., Buabeng, K.O. and Owusu-Dabo, E. (2016). Genotypic characterization of human papillomavirus infections among persons living with HIV infection; a case-control study in Kumasi, Ghana.. Trop Med Int Health, 21(2):275-82.

7. Vinnemeier, C.D., Klupp, E.M., Krumkamp, R., Rolling, T., Fischer, N., Owusu-Dabo, E., Addo, M.M., Adu-Sarkodie, Y., Käsmaier, J., Aepfelbacher, M., Cramer, J.P., May, J. and Tannich, E. (2016). Tropheryma whipplei in children with diarrhoea in rural Ghana. Clin Microbiol Infect, 22(1):65.e1-3

8. Mulder, N.J., Adebiyi, E., Alami, R., Benkahla, A., Brandful, J., Doumbia, S., Everett, D., Fadlelmola, F.M., Gaboun, F., Gaseitsiwe, S., Ghazal, H., Hazelhurst, S., Ibrahimi, A., Hide, W., Jaufeerally Fakim, Y., Jongeneel, V., Joubert, F., Kassim, S., Kayondo, J., Kumuthini, J., Lyantagaye, S., Makani, J., Alzohairy, A.M., Masiga, D., Moussa, A., Nash, O., Ouwe Missi Oukem-Boyer, O., Owusu-Dabo. E., Panji, S., Patterton, H., Radouani, F., Sadki, K., Seghrouchni, F., Tastan Bishop, Ö., Tiffin, N. and Ulenga, N.; H3ABioNet Consortium. (2016). H3ABioNet, a sustainable Pan-African Bioinformatics Network for Human Heredity and Health in Africa. Genome Res., 26(2): 271-7

9. Stockdale, A.J., Phillips, R.O. and Geretti, A.M.; HEPIK Study Group (2016). The gamma-glutamyl transpeptidase to platelet ratio (GPR) shows poor correlation with transient elastography measurements of liver fibrosis in HIV-positive patients with chronic hepatitis B in West Africa. Response to: ‘The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa’ by Lemoine et al. Gut, pii: gutjnl-2015-311133. doi: 10.1136/gutjnl-2015-311133.

Publications 2015

1. Darko, S.N., Yar, D.D., Owusu-Dabo, E,. Afum-Adjei Awuah, A., Dapaah, W., Addofoh, N., Salifu, S.P., Awua-Boateng, NY. and Adomako-Boateng, F. (2015). Variations in levels of IL-6 and TNF-α in type 2 diabetes mellitus between rural and urban Ashanti Region of Ghana. BMC Endocrine Disorders, 15:50.doi:10.1186/s12902-015-0047-9.

2. Sondo, P., Derra, K., Diallo-Nakanabo, S., Tarnagda, Z., Zampa, O., Kazienga, A., Valea, I., Sorgho, H., Owusu-Dabo, E., Ouedraogo, J.B., Guiguemde, T.R. and Tinto, H. (2015). Effectiveness and safety of artemether-lumefantrine versus artesunate-amodiaquine for unsupervised treatment of uncomplicated falciparum malaria in patients of all age groups in Nanoro, Burkina Faso: a randomized open label trial. Malar J., 14(1):325. doi: 10.1186/s12936-015-0843-8.

3. Nakua, E.K., Otupiri, E., Dzomeku, V.M., Owusu-Dabo, E., Agyei-Baffour, P., Yawson, A.E., Folson, G. and Hewlett, S. (2015). Gender disparities of chronic musculoskeletal disorder burden in the elderly Ghanaian population: study on global ageing and adult health (SAGE WAVE 1). BMC Musculoskelet Disord, 16:204. doi: 10.1186/s12891-015-0666-3

4. Vinnemeier, C.D., Brust, P., Owusu-Dabo, E., Sarpong, N., Sarfo, E.Y., Bio, Y., Rolling, T., Dekker, D., Adu-Sarkodie, Y., Eberhardt, K.A,. May, J. and Cramer JP. (2015). Group B Streptococci Serotype Distribution in Pregnant Women in Ghana: Assessment of Potential Coverage Through Future Vaccines. Trop Med Int Health. doi: 10.1111/tmi.12589

5. Meyer, C.G., Intemann, C.D., Förster, B., Owusu-Dabo, E., Franke, A., Horstmann, R.D. and Thye, T. (2015). No significant impact of IFN-γ pathway gene variants on tuberculosis susceptibility in a West African population. Eur J Hum Genet., doi: 10.1038/ejhg.2015.172.

6. Sarpong, N., Owusu-Dabo, E., Kreuels, B., Fobil, J.N., Segbaya, S., Amoyaw, F., Hahn, A., Kruppa. T. and May, J. (2015). Prevalence of malaria parasitaemia in school children from two districts of Ghana earmarked for indoor residual spraying: a cross-sectional study. Malar J., 14:260. doi: 10.1186/s12936-015-0772-6

7. Badu, K., Gyan, B., Appawu, M., Mensah, D., Dodoo, D., Yan, G., Drakeley, C., Zhou, G., Owusu-Dabo, E. and Koram, K.A. (2015). Serological evidence of vector and parasite exposure in Southern Ghana: the dynamics of malaria transmission intensity. Parasit Vectors, 8:251. doi: 10.1186/s13071-015-0861-y.

8. Annan, A., Owusu, M., Marfo, K.S., Larbi, R., Sarpong, F.N., Adu-Sarkodie, Y., Amankwa, J., Fiafemetsi, S., Drosten, C., Owusu-Dabo, E. and Eckerle, I. (2015). High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana, 2013. Trop Med Int Health, 20(6): 807-812.

9. Agyemang, C., Beune, E., Meeks, K., Owusu-Dabo, E., Agyei-Baffour, P., Aikins, Ad., Dodoo, F., Smeeth, L., Addo, J., Mockenhaupt, F.P., Amoah, S.K., Schulze, M.B., Danquah, I., Spranger, J., Nicolaou, M., Klipstein-Grobusch, K., Burr, T., Henneman, P., Mannens, M.M., van Straalen, J.P., Bahendeka, S., Zwinderman, A.H., Kunst, A.E. and Stronks, K. (2015). Rationale and cross-sectional study design of the Research on Obesity and type 2 Diabetes among African Migrants: the RODAM study. BMJ Open, 4(3):e004877. doi: 10.1136/bmjopen-2014-004877.

10. Gyimah, A.A., Nakua, E.K., Owusu-Dabo, E. and Otupiri, E. (2015). Fertility Preferences of Women Living with HIV in the Kumasi Metropolis, Ghana. Afr J Reprod Health, 19 (2): 124-132.

11. Nakua, E., Otupiri, E., Owusu-Dabo, E., Dzomeku, V., Otu-Danquah, K. and Anderson, M. (2015). Prevalence of refractive errors among junior high school students in the Ejisu Juaben municipality of Ghana. Journal of Science and Technology (Ghana), 35:52-62.

12.  Owusu, I., Aryee, C., Owiredu, W., Osei-Yeboah, J., Owusu-Dabo, E. and Laing, E. (2015). Analysis of atherogenic and anthropometric profiles of normotensive and hypertensive Ghanaians in the Kumasi metropolis. British Journal of Medicine and Medical Research, 7:378-397.

13.  Garms, R., Badu, K., Owusu-Dabo, E., Baffour-Awuah, S., Adjei, O., Debrah, A.Y., Nagel, M., Biritwum, N.K., Gankpala, L., Post, R.J. and Kruppa, TF. (2015). Assessments of the transmission of Onchocerca volvulus by Simulium sanctipauli in the Upper Denkyira District, Ghana, and the intermittent disappearance of the vector. Parasitol Res, 114: 1129-1137.

14.  Sothmann, P., Krumkamp, R., Kreuels, B., Sarpong, N., Frank, C., Ehlkes, L., Fobil, J., Gyau, K., Jaeger, A., Bosu, B., Marks, F., Owusu-Dabo, E., Salzberger, B. and May, J. (2015). Urbanicity and paediatric bactaraemia in Ghana- A case-control study within a rural-urban transition zone. PLos One, 10(9).  e0139433.doi: 10.1371/journal.pone.0139433

15.  Nakua, E.K., Sevugu, J.T., Dzomeku, V.M., Otupiri, E., Lipkovich, H.R. and Owusu-Dabo, E. (2015). Home birth without skilled attendants despite millennium villages project intervention in Ghana: insight from a survey of women’s perceptions of skilled obstetric care. BMC Pregnancy Childbirth, 15:243. doi: 10.1186/s12884-015-0674-1.

16.  Japiong, K.B., Asiamah, G., Owusu-Dabo, E., Donkor, P., Stewart, B., Ebel, B.E. and Mock, C.N. (2015). Availability of resources for emergency care at a second-level hospital in Ghana: A mixed methods assessment. African Journal of Emergency Medicine, Doi: http://dx.doi.org/10.1016/j.afjem.2015.06.006

17.  Forbi, J.C., Layden, J.E., Phillips, R.O., Mora, N., Xia, G.L., Campo, D.S., Purdy, M.A., Dimitrova, Z.E., Owusu, D.O., Punkova, L.T., Skums, P., Owusu-Ofori, S., Sarfo, F.S., Vaughan, G., Roh, H., Opare-Sem, O.K., Cooper, R.S. and Khudyakov, YE. (2015). Next-generation sequencing reveals frequent opportunities for exposure to Hepatitis C virus in Ghana. PLoS One, 10(12):e0145530. doi: 10.1371/journal.pone.0145530.

18.  Niang, F., Sarfo, F.S., Frimpong, M., Guenin-Macé, L., Wansbrough-Jones, M., Stinear, T., Phillips, R.O. and Demangel, C. (2015).  Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease. Sci Rep., 5:17693. doi: 10.1038/srep17693.

19.  Sarfo, F.S., Eberhardt, K.A., Dompreh, A., Kuffour, E.O., Soltau, M., Schachscheider, M., Drexler, J.F., Eis-Hübinger, A.M., Häussinger, D., Oteng-Seifah, E.E., Bedu-Addo, G., Phillips, R.O., Norman, B., Burchard, G. and Feldt, T. (2015). Helicobacter pylori infection is associated with higher CD4 T cell counts and lower HIV-1 viral loads in ART-naïve HIV-Positive Patients in Ghana. PLoS One, 10(11):e0143388. doi: 10.1371/journal.pone.0143388.

20.   Beissner, M., Phillips, R.O., Battke, F., Bauer, M., Badziklou, K,, Sarfo, F.S. Maman, I., Rhomberg, A., Piten, E., Frimpong, M., Huber, K.L., Symank, D., Jansson, M., Wiedemann, F.X., Banla Kere, A., Herbinger, K.H., Löscher, T. and Bretzel, G. (2015). Loop-mediated isothermal amplification for Laboratory confirmation of Buruli ulcer disease-towards a Point-of-Care Test. PLoS Negl Trop Dis., 9(11):e0004219. doi: 10.1371/journal.pntd.0004219.

21.  de Zeeuw, J., Alferink, M., Barogui, Y.T., Sopoh, G., Phillips, R.O., van der Werf, T.S., Loth, S., Molenbuur, B., Plantinga, M., Ranchor, A.V. and Stienstra, Y. (2015). Assessment and treatment of pain during treatment of Buruli ulcer. PLoS Negl Trop Dis., 9(9):e0004076. doi: 10.1371/journal.pntd.0004076.

22.  Eberhardt, K.A., Sarfo, F.S., Dompreh, A., Kuffour, E.O., Geldmacher, C., Soltau, M., Schachscheider, M., Drexler, J.F., Eis-Hübinger, A.M., Häussinger, D., Bedu-Addo, G., Phillips, R.O., Norman, B., Burchard, G.D. and Feldt, T. (2015). Helicobacter pylori co-infection Is associated with decreased markers of immune activation in ART-naive HIV-Positive and in HIV-Negative individuals in Ghana. Clin Infect Dis., 61(10): 1615-23.

23.  Alferink, M., de Zeeuw. J., Sopoh, G., Agossadou, C., Abass, K.M., Phillips, R.O., Loth, S., Jutten, E., Barogui, Y.T., Stewart, R.E., van der Werf, T.S., Stienstra, Y. and Ranchor, A.V. (2015). Pain associated with wound care treatment among Buruli ulcer patients from Ghana and Benin. PLoS One, 10(6):e0119926. doi: 10.1371/journal.pone.0119926.

24.  Stockdale, A.J., Phillips, R.O., Beloukas, A., Appiah, L.T., Chadwick, D., Bhagani, S., Bonnett, L., Sarfo, F.S., Dusheiko, G. and Geretti, A.M.; (2015). Hepatitis B Infection in Kumasi (HEPIK) Study Group. Liver fibrosis by transient elastography and virologic outcomes after introduction of Tenofovir in Lamivudine-experienced adults with HIV and Hepatitis B Virus co-infection in Ghana. Clin Infect Dis., 61(6): 883-91.

25.  Phillips, R.O., Phanzu, D.M., Beissner, M., Badziklou, K., Luzolo, E.K., Sarfo, F.S., Halatoko, W.A., Amoako, Y., Frimpong, M., Kabiru, A.M., Piten, E., Maman, I., Bidjada, B., Koba, A., Awoussi, K.S., Kobara, B., Nitschke, J., Wiedemann, F.X., Kere, A.B., Adjei, O., Löscher, T., Fleischer, B., Bretzel, G. and Herbinger, K.H. (2015). Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. PLoS Negl Trop Dis., 9(1):e3457. doi: 10.1371/journal.pntd.0003457.

26.  Layden, J.E., Phillips, R.O., Owusu-Ofori, S., Sarfo, F.S., Kliethermes, S., Mora, N., Owusu, D., Nelson, K., Opare-Sem, O., Dugas, L., Luke, A., Shoham, D., Forbi, J.C., Khudyakov, Y.E. and Cooper, R.S. (2015).  High frequency of active HCV infection among seropositive cases in west Africa and evidence for multiple transmission pathways. Clin Infect Dis., 60(7): 1033-41.

27.  King, S., Adjei-Asante, K., Appiah, L., Adinku, D., Beloukas, A., Atkins, M., Sarfo, S.F., Chadwick, D., Phillips, R.O. and Geretti, A.M. (2015). Antibody screening tests variably overestimate the prevalence of hepatitis C virus infection among HIV-infected adults in Ghana. J Viral Hepat, 22(5): 461-8.

28.  Abass, K.M., van der Werf, T.S., Phillips, R.O., Sarfo, F.S., Abotsi, J., Mireku, S.O., Thompson, W.N., Asiedu, K., Stienstra, Y. and Klis, S.A. (2015). Buruli ulcer control in a highly endemic district in Ghana: role of community-based surveillance volunteers. Am J Trop Med Hyg. 2015, 92(1): 115-7.

29.  Stanton, M.C., Mkwanda, S.Z., Debrah, A.Y., Batsa, L., Biritwum, N.K., Hoerauf, A., Cliffe, M., Best, A., Molineux, A. and Kelly-Hope, L.A. (2015). Developing a community-led SMS reporting tool for the rapid assessment of lymphatic filariasis morbidity burden: case studies from Malawi and Ghana. BMC Infect Dis, 15:214. doi: 10.1186/s12879-015-0946-4.

30.  Debrah, A.Y., Specht, S., Klarmann-Schulz, U., Batsa, L., Mand, S., Marfo-Debrekyei, Y., Fimmers, R., Dubben, B., Kwarteng, A., Osei-Atweneboana, M., Boakye, D., Ricchiuto, A., Büttner, M., Adjei, O., Mackenzie, C.D. and Hoerauf, A. (2015). Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial. Clin Infect Dis, 61(4): 517-26.

31.  Arndts, K., Klarmann-Schulz, U., Batsa, L., Debrah, A.Y., Epp, C., Fimmers, R., Specht, S., Layland, L.E. and Hoerauf, A. (2015). Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals. Parasit Vectors, 8:184. doi: 10.1186/s13071-015-0786-5.

32.  Quintana, J.F., Makepeace, B.L., Babayan, S.A., Ivens, A., Pfarr, K.M., Blaxter, M., Debrah, A., Wanji, S., Ngangyung, H.F., Bah, G.S., Tanya, V.N., Taylor, D.W., Hoerauf, A. and Buck, A.H. (2015). Extracellular Onchocerca-derived small RNAs in host nodules and blood. Parasit Vectors, 8:58. doi: 10.1186/s13071-015-0656-1.

33.  Katawa, G., Layland, L.E., Debrah, A.Y., von Horn, C., Batsa, L., Kwarteng, A., Arriens, S., Taylor, D., Specht, S., Hoerauf, A., and Adjobimey, T. (2015). Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells. PLoS Negl Trop Dis, 9(1):e3414. doi: 10.1371/journal.pntd.0003414.

34.  Rolling, T., Agbenyega, T., Krishna, S., Kremsner, P.G. and Cramer, J.P. (2015). Delayed haemolysis after artesunate treatment of severe malaria – review of the literature and perspective. Travel Med Infect Dis., 13(2): 143-9.

35.  Annan, A., Ebach, F., Corman, V.M., Krumkamp, R., Adu-Sarkodie, Y., Eis-Hübinger, A.M., Kruppa, T., Simon, A., May, J., Evans, J., Drosten, C. and Drexler, JF. (2015). Similar Virus Spectra and Seasonality in Paediatric Patients with Acute Respiratory Disease, Ghana and Germany. Clin Microbiol Infect, pii: S1198-743X(15)00980-5. doi: 10.1016/j.cmi.2015.11.002.

36.  Frickmann, H., Dekker, D., Schwarz, N.G., Hahn, A., Boahen, K., Sarpong, N., Adu-Sarkodie, Y., Halbgewachs, E., Marks, F., von Kalckreuth, V., Poppert, S., Loderstaedt, U., May, J. and Hagen, R.M. (2015). 16S rRNA Gene Sequence-Based Identification of Bacteria in Automatically Incubated Blood Culture Materials from Tropical Sub-Saharan Africa. PLoS One, 10(8):e0135923. doi: 10.1371/journal.pone.0135923.

37.  Krumkamp, R., Sarpong, N., Schwarz, N.G., Adlkofer, J., Loag, W., Eibach, D., Hagen, R.M., Adu-Sarkodie, Y., Tannich, E. and May, J. (2015). Correction: Gastrointestinal infections and diarrheal disease in Ghanaian infants and children: an outpatient case-control study. PLoS Negl Trop Dis., 9(4):e0003728. doi: 10.1371/journal.pntd.0003728.

38.  Nielsen, M.V., Amemasor, S., Agyekum, A., Loag, W., Marks, F., Sarpong, N., Dekker, D., Adu-Sarkodie, Y. and May, J. (2015). Clinical indicators for bacterial co-infection in Ghanaian children with P. falciparum infection. PLoS One, 10(4):e0122139. doi: 10.1371/journal.pone.0122139.

39.  Dekker, D.M., Krumkamp, R., Sarpong, N., Frickmann, H., Boahen, K.G., Frimpong. M., Asare, R., Larbi, R., Hagen, R.M., Poppert, S., Rabsch, W., Marks, F., Adu-Sarkodie, Y. and May, J. (2015). Drinking water from dug wells in rural Ghana–salmonella contamination, environmental factors, and genotypes. Int J Environ Res Public Health, 12(4): 3535-46.

40.  Eibach D, Krumkamp R, Al-Emran HM, Sarpong N, Hagen RM, Adu-Sarkodie Y, Tannich E, May J. (2015). Molecular characterization of Cryptosporidium spp. among children in rural Ghana. PLoS Negl Trop Dis, 9(3):e0003551. doi: 10.1371/journal.pntd.0003551.

41.  Krumkamp, R., Sarpong, N., Schwarz, N.G., Adlkofer, J., Loag, W., Eibach, D., Hagen, R.M., Adu-Sarkodie, Y., Tannich, E. and May, J. (2015). Gastrointestinal infections and diarrheal disease in Ghanaian infants and children: an outpatient case-control study. PLoS Negl Trop Dis., 9(3):e0003568. doi: 10.1371/journal.pntd.0003568. eCollection 2015 Mar. Erratum in: PLoS Negl Trop Dis, 9(4):e0003728. Adelkofer, Julia [corrected to Adlkofer, Julia].

42.  Annan, A.A., Kruppa, T.F., Adjei, O. and Garms, R. (2015). Palp ratio as a field identification tool for two members of the Anopheles gambiae complex in Ghana (A. melas and A. gambiae). Parasit Vectors, 8:295. doi: 10.1186/s13071-015-0913-3.

43.  Annan, A., Ebach, F., Corman, V.M., Krumkamp, R., Adu-Sarkodie, Y., Eis-Hübinger, A.M., Kruppa, T., Simon, A., May, J., Evans, J., Drosten, C. and Drexler, J.F. (2015). Similar virus spectra and seasonality in Paediatric Patients with Acute Respiratory Disease, Ghana and Germany. Clin Microbiol Infect, pii: S1198-743X(15)00980-5. doi: 10.1016/j.cmi.2015.11.002.

44.  Junglen, S., Marklewitz, M., Zirkel, F., Wollny, R., Meyer, B., Heidemann, H., Metzger, S., Annan, A., Dei, D., Leendertz, F.H., Oppong, S. and Drosten, C. (2015). No Evidence of Gouléako and Herbert Virus Infections in Pigs, Côte d’Ivoire and Ghana. Emerg Infect Dis., 21(12): 2190-3.

45.  Corman, V.M., Baldwin, H.J., Tateno, A.F., Zerbinati, R.M., Annan, A., Owusu, M., Nkrumah, E.E., Maganga, G.D., Oppong, S., Adu-Sarkodie, Y., Vallo, P., da Silva Filho, L.V., Leroy, E.M., Thiel, V., van der Hoek, L., Poon, L.L., Tschapka, M., Drosten, C. and Drexler, J.F. (2015). Evidence for an Ancestral Association of Human Coronavirus 229E with Bats. J Virol, 89(23): 11858-70.

46.  Freuling, C.M., Binger, T., Beer, M., Adu-Sarkodie, Y., Schatz, J., Fischer, M., Hanke, D., Hoffmann, B., Höper, D., Mettenleiter, T.C., Oppong, S.K., Drosten, C. and Müller, T. (2015). Lagos bat virus transmission in an Eidolon helvum bat colony, Ghana. Virus Res., 210: 42-5.

47.  Anti, P., Owusu, M., Agbenyega, O., Annan, A., Badu, E.K., Nkrumah, E.E., Tschapka, M., Oppong, S., Adu-Sarkodie, Y. and Drosten, C. (2015). Human-Bat Interactions in Rural West Africa. Emerg Infect Dis., 21(8): 1418-21.

48.  Freidl, G.S., Binger, T., Müller, M.A., de Bruin, E., van Beek, J., Corman, V.M., Rasche, A., Drexler, J.F., Sylverken, A., Oppong, S.K., Adu-Sarkodie, Y., Tschapka, M., Cottontail, V.M., Drosten, C. and Koopmans, M. (2015). Serological evidence of influenza A viruses in frugivorous bats from Africa. PLoS One, 10(5):e0127035. doi: 10.1371/journal.pone.0127035.

49.  Eckerle, I., Annan, A. and Drosten, C. (2015). Response to the letter to the editor: Barasheed et al., ‘No evidence of MERS-CoV in Ghanaian Hajj pilgrims: cautious interpretation is needed’. Trop Med Int Health, 20(8): 1123-4.

50.  Corman, V.M., Grundhoff, A., Baechlein, C., Fischer, N., Gmyl, A., Wollny, R., Dei, D., Ritz, D., Binger, T., Adankwah, E., Marfo, K.S., Annison, L., Annan, A., Adu-Sarkodie, Y., Oppong, S., Becher, P., Drosten, C. and Drexler, J.F. (2015). Highly divergent hepaciviruses from African cattle. J Virol, 89(11): 5876-82.

51.  Binger, T., Annan, A., Drexler, J.F., Müller, M.A., Kallies, R., Adankwah, E., Wollny, R., Kopp, A., Heidemann, H., Dei, D., Agya-Yao, F.C., Junglen, S., Feldt, T., Kurth, A., Oppong, S., Adu-Sarkodie, Y. and Drosten, C. (2015). A novel rhabdovirus isolated from the straw-colored fruit bat Eidolon helvum, with signs of antibodies in swine and humans. J Virol, 89(8): 4588-97.

52.  Schumak, B., Klocke, K., Kuepper, J.M., Biswas, A., Djie-Maletz, A., Limmer, A., van Rooijen, N., Mack, M., Hoerauf, A. and Dunay, I.R. (2015). Specific depletion of Ly6C(hi) inflammatory monocytes prevents immunopathology in experimental cerebral malaria. PLoS One, 10(4):e0124080. doi: 10.1371/journal.pone.0124080.

53.  Oteng, R.A., Whiteside, L.K., Rominski, S.D., Amuasi, J.H., Carter, P.M., Donkor, P. and Cunningham, R. (2015). Individual and Medical Characteristics of Adults Presenting to an Urban Emergency Department in Ghana. Ghana Med J., 49(3): 136-41.

54.  Jagoe, G. and Amuasi, J.H. (2015). Saving lives through improved use of ACTs. Lancet Glob Health, 3(12):e727-8. doi: 10.1016/S2214-109X(15)00208-9.

55.  Poyer, S., Shewchuk, T., Tougher, S., Ye, Y.; ACTwatch Group, Mann, A.G., Willey, B.A., Thomson, R., Amuasi, J.H., Ren, R., Wamukoya, M., Taylor, M., Nguah, S.B., Mberu, B., Kalolella, A., Juma, E., Festo, C., Johanes, B., Diap, G., Bruxvoort, K., Ansong, D., Hanson, K., Arnold, F. and Goodman, C. (2015). Availability and price of malaria rapid diagnostic tests in the public and private health sectors in 2011: results from 10 nationally representative cross-sectional retail surveys. Trop Med Int Health, 20(6): 744-56.

Advance Statistics

The KCCR is pleased to announce a one-week course on applied regression modeling for epidemiological research.

Course Title:
Applied Regression Modeling for Epidemiological Research
Course Date: 9-13 November 2015
Venue: Kumasi Centre For Collaborative Research in Tropical
Medicine (KCCR), KNUST

Lecturers:
From Kumasi, Ghana:
Dr Ellis Owusu-Dabo, KCCR
Dr. Augustina Annan, KCCR
Mr. Nicholas Addofoh, KCCR
Mr. Emmanuel Nakwah, Community Health, SMS, KNUST
Other faculty members from abroad.

Course Outline:
Multivariable regression models are an epidemiological workhorse to associate exposures with outcomes, to adjust for confounding, and assess effect-measure modification. They are also used to predict outcomes. This course introduces the theory and application of regression analysis, focusing on the linear model for continuous outcomes, logistic models for categorical outcomes, models for count responses, and the Cox model for censored survival times.
The rationale for the use of regression models in non-experimental,
observational data will be discussed. Particular emphasis will be placed on the interpretation of parameter estimates, selection of covariables, assessment of non-linearity, confounding, interaction, and predictive accuracy. A brief outline to regression analyses of complex surveys, correlated and longitudinal data, and handling of missing data will be given. Participants will gain practical experience of data analysis using the computer package STATA using public use datasets. Participants are welcome to ask for advice on how to analyse their own data.

Who Should Apply?
Prerequisites are introductory courses to epidemiology, statistics and dataanalysis. All participants must come with their laptops for the practical sessions. The course is taught in Stata and we require participants to have experience of statistical analysis using Stata (for example, simple linear regression). The course is designed primarily for those working, or planning to work, on epidemiological research projects. The emphasis will be on developing an understanding of the underlying assumptions and principles, on the practical application of the techniques and on the correct interpretation of the results, rather than on the mathematical derivation of the methods.

Course Content:
The course makes use of the STATA package throughout. The topics to be covered will include:
• Measures of disease frequency and exposure effects
• Introduction to Regression analysis
• Predictive modeling
• Risk scores
• Logistic regression
• Mantel Haenszel estimator
• Non-linear Modeling
• Models for categorical outcomes
• Confounding and interaction
• Life tables and Kaplan –Meier method
• Semi- parametric regression: Cox regression
• Parametric survival regression models
• Poisson regression
• Survival analysis and hazards functions
• Strategies of analysis.

Participants would benefit much if they already have data to be analysed. Teaching will be through lectures, discussions and practical sessions. There will be a strong emphasis on practical exercises involving participants in the use of computer software to analyse illustrative data-sets from a variety of epidemiological studies. Comprehensive course notes will be given to participants at the beginning of the course. There will be no examination. A certificate of attendance will be issued to those completing the course

Course fee in 2015: GHC 800 (includes Snack, Lunch)

How to apply:
Please download and complete the application form, and submit to the course coordinator at SMS or KCCR, KNUST, by hand or via email (info@kccr.de).

Contact: Emmanuel (SMS) +233 24 6517578
Nicholas (KCCR): +233 26 9621259

Application Deadline: 30th October 2015.

Publications 2014

1. Owusu M, Annan A, Corman VM, Larbi R, Anti P, Drexler JF, Agbenyega O, Adu-Sarkodie Y, Drosten C. Human coronaviruses associated with upper respiratory tract infections in three rural areas of Ghana. PLoS One. 2014 Jul 31;9 (7):e99782.

2. Afum-Adjei Awuah A, Ueberberg B, Owusu-Dabo E, Frempong M, Jacobsen M. Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis. Int Immunol. 2014 , 26(10):579-82.

3. Torgbor C, Awuah P, Deitsch K, Kalantari P, Duca KA, Thorley-Lawson DA. A multifactorial role for P. falciparum malaria in endemic Burkitt’s lymphoma pathogenesis. PLoS Pathog. 2014, 10(5): e1004170.

4. Phillips RO, Sarfo FS, Landier J, Oldenburg R, Frimpong M, Wansbrough-Jones M, Abass K, Thompson W, Forson M, Fontanet A, Niang F, Demangel C. Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease. PLoS Negl Trop Dis. 2014;8(4):e 2786.

5. Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann Schulz U, Mand S, Batsa L, Kwarteng A, Taylor M, Adjei O, Martin C, Layland LE, Hoerauf A. Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels. PLoS Negl Trop Dis. 2014;8(2): e2679.

6. Vandelannoote K, Jordaens K, Bomans P, Leirs H, Durnez L, Affolabi D, Sopoh G, Aguiar J, Phanzu DM, Kibadi K, Eyangoh S, Manou LB, Phillips RO, Adjei O, Ablordey A, Rigouts L, Portaels F, Eddyani M, and de Jong BC. Evolutionary and genomic microbiology insertion sequence element single nucleotide polymorphism typing provides insights into the population structure and evolution of Mycobacterium ulcerans across Africa. Appl. Environ. Microbiol. 2014, 80:3 1197-1209

7. Esser, C., Bachmann, A., Kuhn, D., Schuldt, K., Förster, B., Thiel, M., May, J., Koch-Nolte, F., Yáñez-Mó, M., Sánchez-Madrid, F., Schinkel, A. H., Jalkanen, S., Craig, A. G., Bruchhaus, I. and Horstmann, R. D. Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes. Cellular Microbiology, 2014, (16): 701–708.

8. Sarfo FS, Sarfo MA, Norman B, Phillips R, Chadwick D. Incidence and Determinants of Nevirapine and Efavirenz-Related Skin Rashes in West Africans: Nevirapine’s Epitaph? PloS one, 2014 DOI: 10.1371/journal.pone.0094854

9. Sarfo FS, Sarfo MA, Norman B, Phillips R, Bedu-Addo G, Chadwick D. Risk of Deaths, AIDS-Defining and Non-AIDS Defining Events among Ghanaians on Long-Term Combination Antiretroviral Therapy PloS one, 2014 DOI: 10.1371/journal.pone.0111400

10. Schuldt K, Evans J, Lenzen J, Ehmen C, Mantau B, Sieversten J, Enuameh Y, Osei-Kwakye K, Opoku EC, Browne ENL, Horstmann R, Timann C. Disentangling malaria anaemia. 2014 Malaria Journal (13) Suppl 1.

11. Messersmith L, Beard J, Agyarko-Poku T, Longobardi D, Asafo M, Corneliess C, Daube E, Ashigbie P, Falconer A, Adu-Sarkodie Y. “I can decide to use the property I have to make money”: HIV Vulneability of Bar Workers and Bar Patrons in Kumasi, Ghana. Center for Global Health and Development 2014 – bu.edu

12. Poku T, Longobardi D, Asafo M, Corneliess C, Daube E, Ashigbie P, Falconer A, Adu-Sarkodie Y. HIV Vulnerability of men and women who inject drugs in Kumasi, Ghana. Center for Global Health and Development 2014 – bu.edu

13. Onyango MA, Adu-Sarkodie Y, Adjei R, Agyarko-Poku T, Greem K, Wambugu S, Falconer A, Kopelman CH, Beard J. Understanding the Relationship Dynamics between Female Sex Workers and Their Intimate Partners in Kumasi, Ghana.Center for Global Health and Development 2014

14. Schuldt K, Ehmen C, Evans J, May J, Ansong D, Sievertsen J, Muntau B, Ruge G, Agbenyega T, Horstmann RD. Endothelial protein C receptor gene variants not associated with severe malaria in ghanaian children.PLoS One. 2014 Dec 26;9(12):e115770. doi: 10.1371/journal.pone.0115770.

15. Brinkel J, Krämer A, Krumkamp R, May J, Fobil J. Mobile phone-based mHealth approaches for public health surveillance in sub-Saharan Africa: a systematic review. Int J Environ Res Public Health. 2014,11(11):11559-82.

16. Maganga GD, Bourgarel M, Obame Nkoghe J, N’Dilimabaka N, Drosten C, Paupy C, Morand S, Drexler JF, Leroy EM. Identification of an unclassified paramyxovirus in Coleura afra: a potential case of host specificity. PLoS One. 2014; 9(12):e115588. doi: 10.1371/journal.pone.0115588.

17. Müller MA, Corman VM, Jores J, Meyer B, Younan M, Liljander A, Bosch BJ, Lattwein E, Hilali M, Musa BE, Bornstein S, Drosten C. MERS coronavirus neutralizing antibodies in camels, Eastern Africa, 1983-1997. Emerg Infect Dis. 2014, 20(12):2093-5.

18. Drosten C. Virus ecology: studying animal reservoirs to understand viral emergence.Drug Res (Stuttg). 2014 Nov;64 Suppl 1:S27. doi: 10.1055/s-0033-1358040.

19. Kallies R, Kopp A, Zirkel F, Estrada A, Gillespie TR, Drosten C, Junglen S. Genetic characterization of goutanap virus, a novel virus related to negeviruses, cileviruses and higreviruses. Viruses. 2014, 6(11):4346-57.

20. Drosten C, Kellam P, Memish ZA. Evidence for camel-to-human transmission of MERS coronavirus. N Engl J Med. 2014; 371(14):1359-60.

21. Schuster S, Zirkel F, Kurth A, van Cleef KW, Drosten C, van Rij RP, Junglen S. A unique nodavirus with novel features: mosinovirus expresses two subgenomic RNAs, a capsid gene of unknown origin, and a suppressor of the antiviral RNA interference pathway. J Virol. 2014 Nov; 88(22):13447-59.

22. Zumla A, Al-Tawfiq JA, Enne VI, Kidd M, Drosten C, Breuer J, Muller MA, Hui D, Maeurer M, Bates M, Mwaba P, Al-Hakeem R, Gray G, Gautret P, Al-Rabeeah AA, Memish ZA, Gant V. Rapid point of care diagnostic tests for viral and bacterial respiratory tract infections–needs, advances, and future prospects. Lancet Infect Dis. 2014 Nov;14(11):1123-35. doi: 10.1016/S1473-3099(14)70827-8.

23. Baldwin HJ, Vallo P, Gardner MG, Drosten C, Tschapka M, Stow AJ. Isolation and characterization of 11 novel microsatellite loci in a West African leaf-nosed bat, Hipposideros aff. ruber. BMC Res Notes. 2014 Sep 4;7:607. doi: 10.1186/1756-0500-7-607.

24. Drosten C, Meyer B, Müller MA, Corman VM, Al-Masri M, Hossain R, Madani H, Sieberg A, Bosch BJ, Lattwein E, Alhakeem RF, Assiri AM, Hajomar W, Albarrak AM, Al-Tawfiq JA, Zumla AI, Memish ZA. Transmission of MERS-coronavirus in household contacts. N Engl J Med. 2014; 371(9):828-35.

25. Drexler JF, Grard G, Lukashev AN, Kozlovskaya LI, Böttcher S, Uslu G, Reimerink J, Gmyl AP, Taty-Taty R, Lekana-Douki SE, Nkoghe D, Eis-Hübinger AM, Diedrich S, Koopmans M, Leroy EM, Drosten C. Robustness against serum neutralization of a poliovirus type 1 from a lethal epidemic of poliomyelitis in the Republic of Congo in 2010. Proc Natl Acad Sci U S A. 2014, 111(35):12889-94.

26. Krüger N, Hoffmann M, Drexler JF, Müller MA, Corman VM, Drosten C, Herrler G. Attachment protein G of an African bat henipavirus is differentially restricted in chiropteran and nonchiropteran cells. J Virol. 2014, 88(20):11973-80.

27. Corman VM, Jores J, Meyer B, Younan M, Liljander A, Said MY, Gluecks I, Lattwein E, Bosch BJ, Drexler JF, Bornstein S, Drosten C, Müller MA. Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013. Emerg Infect Dis. 2014, 20(8):1319-22.

28. Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X. Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.J Biol Chem. 2014, 289(37):25783-96.

29. Doherty ML, Owusu-Dabo E, Kantanka OS, Brawer RO, Plumb JD. Type 2 diabetes in a rapidly urbanizing region of Ghana, West Africa: a qualitative study of dietary preferences, knowledge and practices. BMC Public Health. 2014, 14:1069. doi: 10.1186/1471-2458-14-1069.

30. H3Africa Consortium, Rotimi C, Abayomi A, Abimiku A, Adabayeri VM, Adebamowo C, Adebiyi E, Ademola AD, Adeyemo A, Adu D, Affolabi D, Agongo G, Ajayi S, Akarolo-Anthony S, Akinyemi R, Akpalu A, Alberts M, Alonso Betancourt O, Alzohairy AM, Ameni G, Amodu O, Anabwani G, Andersen K, Arogundade F, Arulogun O, Asogun D, Bakare R, Balde N, Baniecki ML, Beiswanger C, Benkahla A, Bethke L, Boehnke M, Boima V, Brandful J, Brooks AI, Brosius FC, Brown C, Bucheton B, Burke DT, Burnett BG, Carrington-Lawrence S, Carstens N, Chisi J, Christoffels A, Cooper R, Cordell H, Crowther N, Croxton T, de Vries J, Derr L, Donkor P, Doumbia S, Duncanson A, Ekem I, El Sayed A, Engel ME, Enyaru JC, Everett D, Fadlelmola FM, Fakunle E, Fischbeck KH, Fischer A, Folarin O, Gamieldien J, Garry RF, Gaseitsiwe S, Gbadegesin R, Ghansah A, Giovanni M, Goesbeck P, Gomez-Olive FX, Grant DS, Grewal R, Guyer M, Hanchard NA, Happi CT, Hazelhurst S, Hennig BJ, Hertz- C, Fowler, Hide W, Hilderbrandt F, Hugo-Hamman C, Ibrahim ME, James R, Jaufeerally-Fakim Y, Jenkins C, Jentsch U, Jiang PP, Joloba M, Jongeneel V, Joubert F, Kader M, Kahn K, Kaleebu P, Kapiga SH, Kassim SK, Kasvosve I, Kayondo J, Keavney B, Kekitiinwa A, Khan SH, Kimmel P, King MC, Kleta R, Koffi M, Kopp J, Kretzler M, Kumuthini J, Kyobe S, Kyobutungi C, Lackland DT, Lacourciere KA, Landouré G, Lawlor R, Lehner T, Lesosky M, Levitt N, Littler K, Lombard Z, Loring JF, Lyantagaye S, Macleod A, Madden EB, Mahomva CR, Makani J, Mamven M, Marape M, Mardon G, Marshall P, Martin DP, Masiga D, Mason R, Mate-Kole M, Matovu E, Mayige M, Mayosi BM, Mbanya JC, McCurdy SA, McCarthy MI, McIlleron H, Mc’Ligeyo SO, Merle C, Mocumbi AO, Mondo C, Moran JV, Motala A, Moxey-Mims M, Mpoloka WS, Msefula CL, Mthiyane T, Mulder N, Mulugeta Gh, Mumba D, Musuku J, Nagdee M, Nash O, Ndiaye D, Nguyen AQ, Nicol M, Nkomazana O, Norris S, Nsangi B, Nyarko A, Nyirenda M, Obe E, Obiakor R, Oduro A, Ofori-Acquah SF, Ogah O, Ogendo S, Ohene-Frempong K, Ojo A, Olanrewaju T, Oli J, Osafo C, Ouwe Missi Oukem-Boyer O, Ovbiagele B, Owen A, Owolabi MO, Owolabi L, Owusu-Dabo E, Pare G, Parekh R, Patterton HG, Penno MB, Peterson J, Pieper R, Plange-Rhule J, Pollak M, Puzak J, Ramesar RS, Ramsay M, Rasooly R, Reddy S, Sabeti PC, Sagoe K, Salako T, Samassékou O, Sandhu MS, Sankoh O, Sarfo FS, Sarr M, Shaboodien G, Sidibe I, Simo G, Simuunza M, Smeeth L, Sobngwi E, Soodyall H, Sorgho H, Sow Bah O, Srinivasan S, Stein DJ, Susser ES, Swanepoel C, Tangwa G, Tareila A, Tastan Bishop O, Tayo B, Tiffin N, Tinto H, Tobin E, Tollman SM, Traoré M, Treadwell MJ, Troyer J, Tsimako-Johnstone M, Tukei V, Ulasi I, Ulenga N, van Rooyen B, Wachinou AP, Waddy SP, Wade A, Wayengera M, Whitworth J, Wideroff L, Winkler CA, Winnicki S, Wonkam A, Yewondwos M, sen T, Yozwiak N, Zar H. Research capacity. Enabling the genomic revolution in Africa. Science. 2014; 344(6190):1346-8.

31. Agyemang C, Beune E, Meeks K, Owusu-Dabo E, Agyei-Baffour P, Aikins Ad, Dodoo F, Smeeth L, Addo J, Mockenhaupt FP, Amoah SK, Schulze MB, Danquah I, Spranger J, Nicolaou M, Klipstein-Grobusch K, Burr T, Henneman P, Mannens MM, van Straalen JP, Bahendeka S, Zwinderman AH, Kunst AE, Stronks K. Rationale and cross-sectional study design of the Research on Obesity and type 2 Diabetes among African Migrants: the RODAM study. BMJ Open. 2014, 4(3):e004877. doi: 10.1136/bmjopen-2014-004877.

32. Pool MS, Otupiri E, Owusu-Dabo E, de Jonge A, Agyemang C. Physical violence during pregnancy and pregnancy outcomes in Ghana. BMC Pregnancy Childbirth. 2014,14:71. doi: 10.1186/1471-2393-14-71.

33. Layden JE, Phillips RO, Owusu-Ofori S, Sarfo FS, Kliethermes S, Mora N, Owusu D, Nelson K, Opare-Sem O, Dugas L, Luke A, Shoham D, Forbi JC, Khudyakov YE, Cooper RS. High Frequency of Active HCV Infection Among Seropositive Cases in West Africa and Evidence for Multiple Transmission Pathways. Clin Infect Dis. 2014. pii: ciu965.

34. King S, Adjei-Asante K, Appiah L, Adinku D, Beloukas A, Atkins M, Sarfo SF, Chadwick D, Phillips RO, Geretti AM. Antibody screening tests variably overestimate the prevalence of hepatitis C virus infection among HIV-infected adults in Ghana. J Viral Hepat. 2014 doi: 10.1111/jvh.12354.

35. de Zeeuw J, Douwstra M, Omansen TF, Sopoh GE, Johnson C, Phillips RO, Alferink M, Saunderson P, Van der Werf TS, Dijkstra PU, Stienstra Y. Psychometric properties of the participation scale among former buruli ulcer patients in Ghana and Benin. PLoS Negl Trop Dis. 2014;8(11):e3254. doi: 10.1371/journal.pntd.0003254.

36. de Zeeuw J, Omansen TF, Douwstra M, Barogui YT, Agossadou C, Sopoh GE, Phillips RO, Johnson C, Abass KM, Saunderson P, Dijkstra PU, van der Werf TS, Stientstra Y. Persisting social participation restrictions among former buruli ulcer patients in Ghana and Benin. PLoS Negl Trop Dis. 2014; 8(11):e3303. doi: 10.1371/journal.pntd.0003303..

37. Phillips RO, Sarfo FS, Abass MK, Frimpong M, Ampadu E, Forson M, Amoako YA, Thompson W, Asiedu K, Wansbrough-Jones M. Reply to “compliance with antimicrobial therapy for buruli ulcer”. Antimicrob Agents Chemother. 2014;58(10):6341.

38. Klis S, Ranchor A, Phillips RO, Abass KM, Tuah W, Loth S, Velding K, van der Werf TS, Stienstra Y. Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. PLoS Negl Trop Dis. 2014;8(7):e2964. doi: 10.1371/journal.pntd.0002964..

39. Klis S, van der Werf TS, Phillips RO, Sarfo FS, Wansbrough-Jones M, Stienstra Y. Oral treatment for patients with Buruli ulcer co-infected with HIV: think twice. AIDS. 2014; 28(5):797-8.

40. Sarfo FS, Thompson W, Phillips RO, Paintsil A, Abass MK, Frimpong M, Abotsi J, Asiedu K, Wansbrough-Jones MH. A severe case of Buruli ulcer disease with pleural effusions. PLoS Negl Trop Dis. 2014;8(6):e2868. doi: 10.1371/journal.pntd.0002868.

41. Phillips RO, Frimpong M, Sarfo FS, Kretschmer B, Beissner M, Debrah A, Ampem-Amoako Y, Abass KM, Thompson W, Duah MS, Abotsi J, Adjei O, Fleischer B, Bretzel G, Wansbrough-Jones M, Jacobsen M. Infection with Mansonella perstans Nematodes in Buruli Ulcer Patients, Ghana. Emerg Infect Dis. 2014 ;20(6):1000-3.

42. Sarfo FS, Phillips RO, Zhang J, Abass MK, Abotsi J, Amoako YA, Adu-Sarkodie Y, Robinson C, Wansbrough-Jones MH. Kinetics of mycolactone in human subcutaneous tissue during antibiotic therapy for Mycobacterium ulcerans disease. BMC Infect Dis. 2014; 14:202. doi: 10.1186/1471-2334-14-202.

43. Phillips RO, Sarfo FS, Landier J, Oldenburg R, Frimpong M, Wansbrough-Jones M, Abass K, Thompson W, Forson M, Fontanet A, Niang F, Demangel C. Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease. PLoS Negl Trop Dis. 2014;8(4):e2786. doi: 10.1371/journal.pntd.0002786.

44. Klis S, Stienstra Y, Phillips RO, Abass KM, Tuah W, van der Werf TS. Long term streptomycin toxicity in the treatment of Buruli Ulcer: follow-up of participants in the BURULICO drug trial. PLoS Negl Trop Dis. 2014 Mar 13;8(3):e2739. doi: 10.1371/journal.pntd.0002739.

45. Jansson M, Beissner M, Phillips RO, Badziklou K, Piten E, Maman I, Sarfo FS, Huber KL, Rhomberg A, Symank D, Wagner M, Wiedemann F, Nitschke J, Banla Kere A, Herbinger KH, Adjei O, Löscher T, Bretzel G. Comparison of two assays for molecular determination of rifampin resistance in clinical samples from patients with Buruli ulcer disease. J Clin Microbiol. 2014; 52(4):1246-9.

46. Phillips RO, Sarfo FS, Abass MK, Abotsi J, Wilson T, Forson M, Amoako YA, Thompson W, Asiedu K, Wansbrough-Jones M. Clinical and bacteriological efficacy of rifampicin-streptomycin combination for two weeks followed by rifampicin and clarithromycin for six weeks for treatment of Mycobacterium ulcerans disease Antimicrob Agents Chemother. 2014;58(2):1161-6. doi: 10.1128/AAC.02165-13. Epub 2013 Dec 9. Erratum in: Antimicrob Agents Chemother. 2014 58(4): 2488.

47. Vandelannoote K, Jordaens K, Bomans P, Leirs H, Durnez L, Affolabi D, Sopoh G, Aguiar J, Phanzu DM, Kibadi K, Eyangoh S, Manou LB, Phillips RO, Adjei O, Ablordey A, Rigouts L, Portaels F, Eddyani M, de Jong BC. Insertion sequence element single nucleotide polymorphism typing provides insights into the population structure and evolution of Mycobacterium ulcerans across Africa. Appl Environ Microbiol. 2014; 80(3):1197-209.

48. Rolling T, Agbenyega T, Issifou S, Adegnika AA, Sylverken J, Spahlinger D, Ansong D, Lohr SJ, Burchard GD, May J, MOrdmuller B, Krishna S, Kremsner PG, Cramer JP. Delayed hemolysis after treatment with parenteral artesuntae in African children with sever malaria-a double-centre prospective study. J Infect Dis. 2014; 209 (12): 1924-8

49. Bristow CC, Adu-Sarkodie Y, Ondondo RO, Bukusi EA, Dagnra CA, Oo KY, Pe EH, Khamsay C, Houng le T, Campuzano RV, Estes J, Klausner JD. Multi-site Laboratory Evaluation of a Dual Human Immunodeficiency Virus (HIV)/Syphilis Point-of-Care Rapid Test for Simultaneous Detection of HIV and Syphilis Infection. Open Forum Infect Dis. 2014; 1(1):ofu015. doi: 10.1093/ofid/ofu015. Mar.

50. Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann Schulz U, Mand S, Batsa L, Kwarteng A, Taylor M, Adjei O, Martin C, Layland LE, Hoerauf A. Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels. PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2679.

51. Coffeng LE, Stolk WA, Hoerauf A, Habbema D, Bakker R, Hopkins AD, de Vlas SJ. Elimination of African onchocerciasis: modeling the impact of increasing the frequency of ivermectin mass treatment. PLoS One. 2014 Dec 29;9(12):e115886. doi: 10.1371/journal.pone.0115886. eCollection 2014.

52. Johnston KL, Ford L, Umareddy I, Townson S, Specht S, Pfarr K, Hoerauf A, Altmeyer R, Taylor MJ. Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis. Int J Parasitol Drugs Drug Resist. 2014 Sep 16;4(3):278-86. doi: 10.1016/j.ijpddr.2014.09.001. eCollection 2014 Dec.

53. Lentz CS, Sattler JM, Fendler M, Gottwalt S, Halls VS, Strassel S, Arriens S, Hannam JS, Specht S, Famulok M, Mueller AK, Hoerauf A, Pfarr KM. In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites. Antimicrob Agents Chemother. 2015 Jan;59(1):654-8. doi: 10.1128/AAC.02383-14. Epub 2014 Oct 13.

54. Lutz P, Berger C, Langhans B, Grünhage F, Appenrodt B, Nattermann J, Lammert F, Hoerauf A, Sauerbruch T, Strassburg CP, Spengler U, Nischalke HD. A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis. Dig Liver Dis. 2014 Nov;46(11):1047-50. doi: 10.1016/j.dld.2014.07.008. Epub 2014 Jul 30.

55. Lutz P, Parcina M, Bekeredjian-Ding I, Nischalke HD, Nattermann J, Sauerbruch T, Hoerauf A, Strassburg CP, Spengler U. Impact of rifaximin on the frequency and characteristics of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites. PLoS One. 2014 Apr 8;9(4):e93909. doi: 10.1371/journal.pone.0093909. eCollection 2014.

56. Albers A, Sartono E, Wahyuni S, Yazdanbakhsh M, Maizels RM, Klarmann-Schulz U, Pfarr K, Hoerauf A. Real-time PCR detection of the HhaI tandem DNA repeat in pre- and post-patent Brugia malayi Infections: a study in Indonesian transmigrants. Parasit Vectors. 2014 Mar 31;7:146. doi: 10.1186/1756-3305-7-146.

57. Ajendra J, Specht S, Neumann AL, Gondorf F, Schmidt D, Gentil K, Hoffmann WH, Taylor MJ, Hoerauf A, Hübner MP. ST2 deficiency does not impair type 2 immune responses during chronic filarial infection but leads to an increased microfilaremia due to an impaired splenic microfilarial clearance. PLoS One. 2014 Mar 24;9(3):e93072. doi: 10.1371/journal.pone.0093072. eCollection 2014.

58. Arndts K, Specht S, Debrah AY, Tamarozzi F, Klarmann Schulz U, Mand S, Batsa L, Kwarteng A, Taylor M, Adjei O, Martin C, Layland LE, Hoerauf A. Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels. PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2679.

59. Lentz CS, Halls VS, Hannam JS, Strassel S, Lawrence SH, Jaffe EK, Famulok M, Hoerauf A, Pfarr KM. wALADin benzimidazoles differentially modulate the function of porphobilinogen synthase orthologs. J Med Chem. 2014 Mar 27;57(6):2498-510. doi: 10.1021/jm401785n. Epub 2014 Feb 25.

60. Arumugam S, Hoerauf A, Pfarr KM. Localization of a filarial phosphate permease that is up-regulated in response to depletion of essential Wolbachia endobacteria. Exp Parasitol. 2014 Mar;138:30-9. doi: 10.1016/j.exppara.2014.01.006. Epub 2014 Jan 28.

61. Gentil K, Lentz CS, Rai R, Muhsin M, Kamath AD, Mutluer O, Specht S, Hübner MP, Hoerauf A. Eotaxin-1 is involved in parasite clearance during chronic filarial infection. Parasite Immunol. 2014 Feb;36(2):60-77. doi: 10.1111/pim.12079.

62. Schäberle TF, Schiefer A, Schmitz A, König GM, Hoerauf A, Pfarr K. Corallopyronin A – a promising antibiotic for treatment of filariasis. Int J Med Microbiol. 2014 Jan;304(1):72-8.

63. Taylor MJ, Hoerauf A, Townson S, Slatko BE, Ward SA. Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis. Parasitology. 2014 Jan;141(1):119-27. doi: 10.1017/S0031182013001108. Epub 2013 Jul 18. Review.

64. Adjobimey T, Satoguina J, Oldenburg J, Hoerauf A, Layland LE. Co-activation through TLR4 and TLR9 but not TLR2 skews Treg-mediated modulation of Igs and induces IL-17 secretion in Treg: B cell co-cultures. Innate Immun. 2014 Jan;20(1):12-23. doi: 10.1177/1753425913479414. Epub 2013 Mar 25.

65. Lutz P, Parcina M, Bekeredjian-Ding I, Hoerauf A, Strassburg CP, Spengler U. Spontaneous bacterial peritonitis by Pasteurella multocida under treatment with rifaximin. Infection. 2014 Feb;42(1):175-7. doi: 10.1007/s15010-013-0449-4. Epub 2013 Mar 25.

Publications 2010

1. Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J, Sirugo G, Diday-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K, Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C, Adegola RA, Corrah T, Ziegler A, Morris AP, Meyer CG, Horstmann RD, Hill AVS, African TB Genetics Consortium & The Wellcome Trust Case Control Consortium.Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11. 2. Nature Genetics. 2010, 42: 739-741.

2. Owusu-Dabo E, McNeill A, Lewis A, Gilmore A, Britton J. Status of implementation of Framework Convention on Tobacco Control (FCTC) in Ghana: a qualitative study. BMC Public Health. 2010, 10:1

3. Homolka S, Meyer CG, Hillemann D, Owusu-Dabo E, Adjei O, Horstmann RD, Browne ENL, Chinbuah A, Osei I, Gyapong J, Kubica T, Ruesch-Gerdes S, Niemann S. Unequal distribution of resistance-conferring mutations among Mycobacterium tuberculosis and Mycobacterium africanum strains from Ghana. Int J Med Microbiol. 2010, 300 (7): 489-495.

4. Kwakye KO, Otupiri E, Owusu-Dabo E, Browne ENL, Adjuik M. Determinants of Under-Five Mortality in Builsa District, Upper East Region, Ghana. Journal Of Science and Technology (Ghana). 2010, 30(1): 45-53.

5. Owusu-Dabo E. Smoking in Ghana: a study of the history of tobacco industry activity, current prevalence and risk factors for smoking, and implementation of tobacco control policy. 2011. uk.bl.ethos.546578.

6. Mombo IM, Berthet N, Lukashev AN, Bleicker T, Brünink S, Léger L, Atencia R, Cox D, Bouchier C, Durand P, Arnathau C, Brazier L, Fair JN, Schneider BS, Drexler JF, Prugnolle F, Drosten C, Renaud F, Leroy EM, Rougeron V. First Detection of an Enterovirus C99 in a Captive Chimpanzee with Acute Flaccid Paralysis, from the Tchimpounga Chimpanzee Rehabilitation Center, Republic of Congo. PLoS One. 2015 Aug 24;10(8):e0136700. doi: 10.1371/journal.pone.0136700. eCollection 2015.

7. Lekana-Douki SE, Kombila-Koumavor C, Nkoghe D, Drosten C, Drexler JF, Leroy EM. Molecular epidemiology of enteric viruses and genotyping of rotavirus A, adenovirus and astrovirus among children under 5 years old in Gabon. Int J Infect Dis. 2015 May;34:90-5. doi: 10.1016/j.ijid.2015.03.009. Epub 2015 Mar 18.

8. Drexler JF, Grard G, Lukashev AN, Kozlovskaya LI, Böttcher S, Uslu G, Reimerink J, Gmyl AP, Taty-Taty R, Lekana-Douki SE, Nkoghe D, Eis-Hübinger AM, Diedrich S, Koopmans M, Leroy EM, Drosten C. Robustness against serum neutralization of a poliovirus type 1 from a lethal epidemic of poliomyelitis in the Republic of Congo in 2010. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12889-94. doi: 10.1073/pnas.1323502111. Epub 2014 Aug 18.

9. Lekana-Douki SE, Nkoghe D, Drosten C, Ngoungou EB, Drexler JF, Leroy EM. Viral etiology and seasonality of influenza-like illness in Gabon, March 2010 to June 2011. BMC Infect Dis. 2014 Jul 7;14:373. doi: 10.1186/1471-2334-14-373.

10. Lekana-Douki SE, Mouinga-Ondémé A, Nkoghe D, Drosten C, Drexler JF, Kazanji M, Leroy EM. Early introduction and delayed dissemination of pandemic influenza, Gabon. Emerg Infect Dis. 2013 Apr;19(4):644-7. doi: 10.3201/eid1904.111925.

11. Lukashev AN, Drexler JF, Kotova VO, Amjaga EN, Reznik VI, Gmyl AP, Grard G, Taty Taty R, Trotsenko OE, Leroy EM, Drosten C. Novel serotypes 105 and 116 are members of distinct subgroups of human enterovirus C. J Gen Virol. 2012 Nov;93(Pt 11):2357-62. doi: 10.1099/vir.0.043216-0. Epub 2012 Aug 15.

12. Maganga GD, Bourgarel M, Ella GE, Drexler JF, Gonzalez JP, Drosten C, Leroy EM. Is Marburg virus enzootic in Gabon? J Infect Dis. 2011 Nov;204 Suppl 3:S800-3. doi: 10.1093/infdis/jir358.

13. Drexler JF, Corman VM, Wegner T, Tateno AF, Zerbinati RM, Gloza-Rausch F, Seebens A, Müller MA, Drosten C. Amplification of emerging viruses in a bat colony. Emerg Infect Dis. 2011 Mar;17(3):449-56. doi: 10.3201/eid1703.100526.

14. Grard G, Drexler JF, Lekana-Douki S, Caron M, Lukashev A, Nkoghe D, Gonzalez JP, Drosten C, Leroy E. Type 1 wild poliovirus and putative enterovirus 109 in an outbreak of acute flaccid paralysis in Congo, October-November 2010. Euro Surveill. 2010 Nov 25;15(47). pii: 19723.

15. Drexler JF, Grywna K, Lukashev A, Stöcker A, Almeida PS, Wieseler J, Ribeiro TC, Petersen N, Ribeiro Hda C Jr, Belalov I, Kümmerer BM, Drosten C. Full genome sequence analysis of parechoviruses from Brazil reveals geographical patterns in the evolution of non-structural genes and intratypic recombination in the capsid region. J Gen Virol. 2011 Mar;92(Pt 3):564-71. doi: 10.1099/vir.0.022525-0. Epub 2010 Dec 1.

16. Carneiro AJ, Franke CR, Stocker A, Dos Santos F, Ungar de Sa JE, Moraes-Silva E, Alves JN, Brunink S, Corman VM, Drosten C, Drexler JF. Rabies virus RNA in naturally infected vampire bats, northeastern Brazil. Emerg Infect Dis. 2010 Dec;16(12):2004-6. doi: 10.3201/eid1612.100726.

17. Thomas S, Rai J, John L, Günther S, Drosten C, Pützer BM, Schaefer S. Functional dissection of the alphavirus capsid protease: sequence requirements for activity. Virol J. 2010 Nov 18;7:327. doi: 10.1186/1743-422X-7-327.

18. Panning M, Baumgarte S, Laue T, Bierbaum S, Raith S, Drexler JF, Helmer A, Falcone-Kapper V, Kochs G, Campe H, Huzly D, Eis-Hübinger AM, Drosten C. Singleplex real-time RT-PCR for detection of influenza A virus and simultaneous differentiation of A/H1N1v and evaluation of the RealStar influenza kit. J Clin Virol. 2011 Feb;50(2):171-4. doi: 10.1016/j.jcv.2010.10.010. Epub 2010 Nov 13.

19. Drexler JF, Gloza-Rausch F, Glende J, Corman VM, Muth D, Goettsche M, Seebens A, Niedrig M, Pfefferle S, Yordanov S, Zhelyazkov L, Hermanns U, Vallo P, Lukashev A, Müller MA, Deng H, Herrler G, Drosten C. Genomic characterization of severe acute respiratory syndrome-related coronavirus in European bats and classification of coronaviruses based on partial RNA-dependent RNA polymerase gene sequences. J Virol. 2010 Nov;84(21):11336-49. doi: 10.1128/JVI.00650-10. Epub 2010 Aug 4.

20. Wenzel JJ, Panning M, Kaul KL, Mangold KA, Revell PA, Luna RA, Zepeda H, Perea L, Vazquez-Perez JA, Young S, Rodic-Polic B, Eickmann M, Drosten C, Jilg W, Reischl U. Analytical performance determination and clinical validation of the novel Roche RealTime Ready Influenza A/H1N1 Detection Set. J Clin Microbiol. 2010 Sep;48(9):3088-94. doi: 10.1128/JCM.00785-10. Epub 2010 Jul 7.

21. Panning M, Kobbe R, Vollbach S, Drexler JF, Adjei S, Adjei O, Drosten C, May J, Eis-Hubinger AM. Novel human parvovirus 4 genotype 3 in infants, Ghana. Emerg Infect Dis. 2010 Jul;16(7):1143-6. doi: 10.3201/eid1607.100025.

22. Zhou Y, Lu K, Pfefferle S, Bertram S, Glowacka I, Drosten C, Pöhlmann S, Simmons G. A single asparagine-linked glycosylation site of the severe acute respiratory syndrome coronavirus spike glycoprotein facilitates inhibition by mannose-binding lectin through multiple mechanisms. J Virol. 2010 Sep;84(17):8753-64. doi: 10.1128/JVI.00554-10. Epub 2010 Jun 23.

23. Panning M, Baumgarte S, Pfefferle S, Maier T, Martens A, Drosten C. Comparative analysis of rabies virus reverse transcription-PCR and virus isolation using samples from a patient infected with rabies virus. J Clin Microbiol. 2010 Aug;48(8):2960-2. doi: 10.1128/JCM.00728-10. Epub 2010 Jun 16.

24. Panning M, Emmerich P, Olschläger S, Bojenko S, Koivogui L, Marx A, Lugala PC, Günther S, Bausch DG, Drosten C. Laboratory diagnosis of Lassa fever, Liberia. Emerg Infect Dis. 2010 Jun;16(6):1041-3. doi: 10.3201/eid1606.100040.

25. Fischer N, Schulz C, Stieler K, Hohn O, Lange C, Drosten C, Aepfelbacher M. Xenotropic murine leukemia virus-related gammaretrovirus in respiratory tract. Emerg Infect Dis. 2010 Jun;16(6):1000-2. doi: 10.3201/eid1606.100066.

26. Grywna K, Kupfer B, Panning M, Drexler JF, Emmerich P, Drosten C, Kümmerer BM. Detection of all species of the genus Alphavirus by reverse transcription-PCR with diagnostic sensitivity. J Clin Microbiol. 2010 Sep;48(9):3386-7.

27. Olschläger S, Lelke M, Emmerich P, Panning M, Drosten C, Hass M, Asogun D, Ehichioya D, Omilabu S, Günther S. Improved detection of Lassa virus by reverse transcription-PCR targeting the 5′ region of S RNA. J Clin Microbiol. 2010 Jun;48(6):2009-13. doi: 10.1128/JCM.02351-09. Epub 2010 Mar 29.

28. Mordstein M, Neugebauer E, Ditt V, Jessen B, Rieger T, Falcone V, Sorgeloos F, Ehl S, Mayer D, Kochs G, Schwemmle M, Günther S, Drosten C, Michiels T, Staeheli P. Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. J Virol. 2010 Jun;84(11):5670-7. doi: 10.1128/JVI.00272-10. Epub 2010 Mar 24.

29. Eis-Hübinger AM, Drexler JF, Reber U, Panning M, Drosten C, Weber-Schehl M, Hedges D, Baylis SA, Roth WK. Absence of detection of novel human parvoviruses in German plasma donations. Transfusion. 2010 Jan;50(1):266-7. doi: 10.1111/j.1537-2995.2009.02433.x.

30. Maier T, Schwarting A, Mauer D, Ross RS, Martens A, Kliem V, Wahl J, Panning M, Baumgarte S, Müller T, Pfefferle S, Ebel H, Schmidt J, Tenner-Racz K, Racz P, Schmid M, Strüber M, Wolters B, Gotthardt D, Bitz F, Frisch L, Pfeiffer N, Fickenscher H, Sauer P, Rupprecht CE, Roggendorf M, Haverich A, Galle P, Hoyer J, Drosten C. Management and outcomes after multiple corneal and solid organ transplantations from a donor infected with rabies virus. Clin Infect Dis. 2010 Apr 15;50(8):1112-9. doi: 10.1086/651267.

31. Drexler JF, Baumgarte S, Luna LK, Stöcker A, Almeida PS, Ribeiro TC, Petersen N, Herzog P, Pedroso C, Brites C, Ribeiro Hda C Jr, Gmyl A, Drosten C, Lukashev A. Genomic features and evolutionary constraints in Saffold-like cardioviruses. J Gen Virol. 2010 Jun;91(Pt 6):1418-27. doi: 10.1099/vir.0.018887-0. Epub 2010 Feb 3.

32. Calvert J, Chieochansin T, Benschop KS, McWilliam Leitch EC, Drexler JF, Grywna K, da Costa Ribeiro H Jr, Drosten C, Harvala H, Poovorawan Y, Wolthers KC, Simmonds P. Recombination dynamics of human parechoviruses: investigation of type-specific differences in frequency and epidemiological correlates. J Gen Virol. 2010 May;91(Pt 5):1229-38. doi: 10.1099/vir.0.018747-0. Epub 2010 Jan 20.

33. Müller MA, van der Hoek L, Voss D, Bader O, Lehmann D, Schulz AR, Kallies S, Suliman T, Fielding BC, Drosten C, Niedrig M. Human coronavirus NL63 open reading frame 3 encodes a virion-incorporated N-glycosylated membrane protein. Virol J. 2010 Jan 15;7:6. doi: 10.1186/1743-422X-7-6.

34. Reusken CB, Lina PH, Pielaat A, de Vries A, Dam-Deisz C, Adema J, Drexler JF, Drosten C, Kooi EA. Circulation of group 2 coronaviruses in a bat species common to urban areas in Western Europe. Vector Borne Zoonotic Dis. 2010 Oct;10(8):785-91. doi: 10.1089/vbz.2009.0173. Epub 2010 Jan 7.

35. Schottstedt V, Blümel J, Burger R, Drosten C, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Montag-Lessing T, Offergeld R, Pauli G, Seitz R, Schlenkrich U, Strobel J, Willkommen H, von König CH. Human Cytomegalovirus (HCMV) – Revised. Transfus Med Hemother. 2010;37(6):365-375. Epub 2010 Nov 17.

36. Pauli G, Blümel J, Burger R, Drosten C, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Montag-Lessing T, Offergeld R, Seitz R, Schlenkrich U, Schottstedt V, Strobel J, Willkommen H, von König CH. Orthopox Viruses: Infections in Humans. Transfus Med Hemother. 2010;37(6):351-364. Epub 2010 Nov 17.

37. Blümel J, Burger R, Drosten C, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Montag-Lessing T, Offergeld R, Pauli G, Seitz R, Schlenkrich U, Schottstedt V, Strobel J, Willkommen H, von König CH. Parvovirus B19 – Revised. Transfus Med Hemother. 2010;37(6):339-350. Epub 2010 Nov 17.

38. Edelmann A, Kalus U, Oltmann A, Stein A, Unbehaun A, Drosten C, Krüger DH, Hofmann. Improvement of an ultrasensitive human immunodeficiency virus type 1 real-time reverse transcriptase-polymerase chain reaction targeting the long terminal repeat region. J. Transfusion. 2010 Mar;50(3):685-92. doi: 10.1111/j.1537-2995.2009.
39. Glowacka I, Bertram S, Herzog P, Pfefferle S, Steffen I, Muench MO, Simmons G, Hofmann H, Kuri T, Weber F, Eichler J, Drosten C, Pöhlmann S. Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63. J Virol. 2010 Jan;84(2):1198-205. doi: 10.1128/JVI.01248-09. Epub 2009 Oct 28.

40. Dassah ET, Adu-Sarkodie Y, Mayaud P. Factors associated with failure to screen for syphilis during antenatal care in Ghana: a case control study. BMC Infect Dis. 2015 Mar 13;15:125. doi: 10.1186/s12879-015-0868-1.

41. Owusu M, Nguah SB, Boaitey YA, Badu-Boateng E, Abubakr AR, Lartey RA, Adu-Sarkodie Y. Aetiological agents of cerebrospinal meningitis: a retrospective study from a teaching hospital in Ghana. Ann Clin Microbiol Antimicrob. 2012 Oct 4;11:28. doi: 10.1186/1476-0711-11-28.

42. Adanu R, Adu-Sarkodie Y, Opare-Sem O, Nkyekyer K, Donkor P, Lawson A, Engleberg NC. Electronic learning and open educational resources in the health sciences in Ghana. Ghana Med J. 2010 Dec;44(4):159-62.

43. Schwarz NG, Sarpong N, Hünger F, Marks F, Acquah SE, Agyekum A, Nkrumah B, Loag W, Hagen RM, Evans JA, Dekker D, Fobil JN, Meyer CG, May J, Adu-Sarkodie Y. Systemic bacteraemia in children presenting with clinical pneumonia and the impact of non-typhoid salmonella (NTS). BMC Infect Dis. 2010 Nov 4;10:319. doi: 10.1186/1471-2334-10-319.

44. Marks F, Adu-Sarkodie Y, Hünger F, Sarpong N, Ekuban S, Agyekum A, Nkrumah B, Schwarz NG, Favorov MO, Meyer CG, May J. Typhoid fever among children, Ghana. Emerg Infect Dis. 2010 Nov;16(11):1796-7. doi: 10.3201/eid1611.100388.

45. Krefis AC, Schwarz NG, Nkrumah B, Acquah S, Loag W, Sarpong N, Adu-Sarkodie Y, Ranft U, May J. Principal component analysis of socioeconomic factors and their association with malaria in children from the Ashanti Region, Ghana. Malar J. 2010 Jul 13;9:201. doi: 10.1186/1475-2875-9-201.

46. Nkrumah B, Agyekum A, Acquah SE, May J, Tannich E, Brattig N, Nguah SB, von Thien H, Adu-Sarkodie Y, Huenger F. Comparison of the novel Partec rapid malaria test to the conventional Giemsa stain and the gold standard real-time PCR. J Clin Microbiol. 2010 Aug;48(8):2925-8. doi: 10.1128/JCM.02403-09. Epub 2010 Jun 16.

47. Sarpong N, Loag W, Fobil J, Meyer CG, Adu-Sarkodie Y, May J, Schwarz NG. National health insurance coverage and socio-economic status in a rural district of Ghana. Trop Med Int Health. 2010 Feb;15(2):191-7. doi: 10.1111/j.1365-3156.2009.02439.x. Epub 2009 Dec 4.

48. Mand S, Debrah AY, Klarmann U, Mante S, Kwarteng A, Batsa L, Marfo-Debrekyei Y, Adjei O, Hoerauf A. The role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis. Acta Trop. 2011 Sep;120 Suppl 1:S23-32. doi: 10.1016/j.actatropica.2010.07.002. Epub 2010 Jul 29

49. Phillips RO, Phanzu DM, Beissner M, Badziklou K, Luzolo EK, Sarfo FS, Halatoko WA, Amoako Y, Frimpong M, Kabiru AM, Piten E, Maman I, Bidjada B, Koba A, Awoussi KS, Kobara B, Nitschke J, Wiedemann FX, Kere AB, Adjei O, Löscher T, Fleischer B, Bretzel G, Herbinger KH. Effectiveness of routine BCG vaccination on buruli ulcer disease: a case-control study in the Democratic Republic of Congo, Ghana and Togo. PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3457. doi: 10.1371/journal.pntd.0003457. eCollection 2015 Jan.

50. Phillips RO, Frimpong M, Sarfo FS, Kretschmer B, Beissner M, Debrah A, Ampem-Amoako Y, Abass KM, Thompson W, Duah MS, Abotsi J, Adjei O, Fleischer B, Bretzel G, Wansbrough-Jones M, Jacobsen M. Infection with Mansonella perstans Nematodes in Buruli Ulcer Patients, Ghana. Emerg Infect Dis. 2014 Jun;20(6):1000-3. doi: 10.3201/eid2006.131501.

51. Geretti AM, Patel M, Sarfo FS, Chadwick D, Verheyen J, Fraune M, Garcia A, Phillips RO. Detection of highly prevalent hepatitis B virus coinfection among HIV-seropositive persons in Ghana. J Clin Microbiol. 2010 Sep;48(9):3223-30. doi: 10.1128/JCM.02231-09. Epub 2010 Jul 14.

52. Sarfo FS, Phillips RO, Rangers B, Mahrous EA, Lee RE, Tarelli E, Asiedu KB, Small PL, Wansbrough-Jones MH. Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue. PLoS Negl Trop Dis. 2010 Jan 5;4(1):e577.

53. Buchholz U, Kobbe R, Danquah I, Zanger P, Reither K, Abruquah HH, Grobusch MP, Ziniel P, May J, Mockenhaupt FP. Multiplicity of Plasmodium falciparum infection following intermittent preventive treatment in infants. Malar J. 2010 Aug 26;9:244. doi: 10.1186/1475-2875-9-244.

54. Krefis AC, Schwarz NG, Nkrumah B, Acquah S, Loag W, Sarpong N, Adu-Sarkodie Y, Ranft U, May J. Principal component analysis of socioeconomic factors and their association with malaria in children from the Ashanti Region, Ghana. Malar J. 2010 Jul 13;9:201. doi: 10.1186/1475-2875-9-201.

55. Kreuels B, Kreuzberg C, Kobbe R, Ayim-Akonor M, Apiah-Thompson P, Thompson B, Ehmen C, Adjei S, Langefeld I, Adjei O, May J. Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth. Blood. 2010 Jun 3;115(22):4551-8. doi: 10.1182/blood-2009-09-241844. Epub 2010 Mar 15.

56. Schuldt K, Esser C, Evans J, May J, Timmann C, Ehmen C, Loag W, Ansong D, Ziegler A, Agbenyega T, Meyer CG, Horstmann RD. FCGR2A functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children. J Med Genet. 2010 Jul;47(7):471-5. doi: 10.1136/jmg.2009.073643. Epub 2009 Dec 3.

57. Thye T, Ehmen C, Intemann CD, Chinbuah MA, Ziegler A, Horstmann RD, Meyer CG. Rare human IFNG variants. J Interferon Cytokine Res. 2010 Apr;30(4):219-22. doi: 10.1089/jir.2009.0042.

58. Möller M, Flachsbart F, Till A, Thye T, Horstmann RD, Meyer CG, Osei I, van Helden PD, Hoal EG, Schreiber S, Nebel A, Franke A. A functional haplotype in the 3’untranslated region of TNFRSF1B is associated with tuberculosis in two African populations. Am J Respir Crit Care Med. 2010 Feb 15;181(4):388-93. doi: 10.1164/rccm.200905-0678OC. Epub 2009 Dec 10.

59. Hoerauf A. Microflora, helminths, and the immune system—who controls whom? N Engl J Med. 2010 Oct 7;363(15):1476-8. doi: 10.1056/NEJMcibr1007689.

60. Adjobimey T, Hoerauf A. Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation. Ann Trop Med Parasitol. 2010 Sep;104(6):455-64.

61. Brattig NW, Racz P, Hoerauf A, Büttner DW. Strong expression of TGF-beta in human host tissues around subcutaneous Dirofilaria repens. Parasitol Res. 2011 Jun;108(6):1347-54. doi: 10.1007/s00436-010-2028-2. Epub 2010 Sep 1.

62. Taylor MJ, Hoerauf A, Bockarie M. Lymphatic filariasis and onchocerciasis. Lancet. 2010 Oct 2;376(9747):1175-85. doi: 10.1016/S0140-6736(10)60586-7. Epub 2010 Aug 23. Review.
63. Niebel B, Lentz C, Pofahl M, Mayer G, Hoerauf A, Pfarr KM, Famulok M. ADLOC: an aptamer-displacement assay based on luminescent oxygen channeling. Chemistry. 2010 Sep 24;16(36):11100-7. doi: 10.1002/chem.201001192.

64. Korten S, Hoerauf A, Kaifi JT, Büttner DW. Low levels of transforming growth factor-beta (TGF-beta) and reduced suppression of Th2-mediated inflammation in hyperreactive human onchocerciasis. Parasitology. 2011 Jan;138(1):35-45. doi: 10.1017/S0031182010000922. Epub 2010 Jul 12.

65. Brattig NW, Tenner-Racz K, Korten S, Hoerauf A, Büttner DW. Immunohistology of ectopic secondary lymph follicles in subcutaneous nodules from patients with hyperreactive onchocerciasis (sowda). Parasitol Res. 2010 Aug;107(3):657-66. doi: 10.1007/s00436-010-1912-0. Epub 2010 Jun 4.

66. Specht S, Ruiz DF, Dubben B, Deininger S, Hoerauf A. Filaria-induced IL-10 suppresses murine cerebral malaria. Microbes Infect. 2010 Aug;12(8-9):635-42. doi: 10.1016/j.micinf.2010.04.006. Epub 2010 Apr 24.

67. Turner JD, Tendongfor N, Esum M, Johnston KL, Langley RS, Ford L, Faragher B, Specht S, Mand S, Hoerauf A, Enyong P, Wanji S, Taylor MJ. Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial. PLoS Negl Trop Dis. 2010 Apr 13;4(4):e660. doi: 10.1371/journal.pntd.0000660.

68. Strübing U, Lucius R, Hoerauf A, Pfarr KM. Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodes. Int J Parasitol. 2010 Aug 15;40(10):1193-202. doi: 10.1016/j.ijpara.2010.03.004. Epub 2010 Apr 1.

69. Korten S, Kaifi JT, Büttner DW, Hoerauf A. Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia. Microbes Infect. 2010 Jul;12(7):555-64. doi: 10.1016/j.micinf.2010.03.011. Epub 2010 Mar 30.

70. Langhans B, Braunschweiger I, Arndt S, Schulte W, Satoguina J, Layland LE, Vidovic N, Hoerauf A, Oldenburg J, Sauerbruch T, Spengler U. Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C. Clin Sci (Lond). 2010 Apr 20;119(2):97-109. doi: 10.1042/CS20090661.

71. Brattig NW, Hoerauf A, Fischer PU, Liebau E, Bandi C, Debrah A, Büttner M, Büttner DW. Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells. Parasitology. 2010 Apr;137(5):841-54. doi: 10.1017/S0031182009992010. Epub 2010 Mar 4.

72. Layland LE, Mages J, Loddenkemper C, Hoerauf A, Wagner H, Lang R, da Costa CU. Pronounced phenotype in activated regulatory T cells during a chronic helminth infection. J Immunol. 2010 Jan 15;184(2):713-24. doi: 10.4049/jimmunol.0901435. Epub 2009 Dec 9.

73. Blavid R, Kusch P, Hauber J, Eschweiler U, Sarite SR, Specht S, Deininger S, Hoerauf A, Kaiser A. Down-regulation of hypusine biosynthesis in Plasmodium by inhibition of S-adenosyl-methionine-decarboxylase. Amino Acids. 2010 Feb;38(2):461-9.

74. Wansi JD, Hussain H, Tcho AT, Kouam SF, Specht S, Sarite SR, Hoerauf A, Krohn K. Antiplasmodial activities of furoquinoline alkaloids from Teclea afzelii.Phytother Res. 2010 May;24(5):775-7. doi: 10.1002/ptr.2894.

75. Jacobsen M, Repsilber D, Kleinsteuber K, Gutschmidt A, Schommer-Leitner S, Black G, Walzl G, Kaufmann SH. Suppressor of cytokine signaling-3 is affected in T-cells from tuberculosisTB patients. Clin Microbiol Infect. 2011 Sep;17(9):1323-31. doi: 10.1111/j.1469-0691.2010.03326.x. Epub 2010 Jul 29.

76. Day TA, Koch M, Nouailles G, Jacobsen M, Kosmiadi GA, Miekley D, Kuhlmann S, Jörg S, Gamradt P, Mollenkopf HJ, Hurwitz R, Reece ST, Kaufmann SH, Kursar M. Secondary lymphoid organs are dispensable for the development of T-cell-mediated immunity during tuberculosis. Eur J Immunol. 2010 Jun;40(6):1663-73. doi: 10.1002/eji.201040299.

77. Faist B, Fleischer B, Jacobsen M. Cytomegalovirus infection- and age-dependent changes in human CD8+ T-cell cytokine expression patterns. Clin Vaccine Immunol. 2010 Jun;17(6):986-92. doi: 10.1128/CVI.00455-09. Epub 2010 Apr 28.

78. Repsilber D, Kern S, Telaar A, Walzl G, Black GF, Selbig J, Parida SK, Kaufmann SH, Jacobsen M. Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach. BMC Bioinformatics. 2010 Jan 14;11:27. doi: 10.1186/1471-2105-11-27.

Publications 2011

1. Fendt L, Röck A, Zimmermann B, Bodner M, Thye T, Tschentscher F, Owusu-Dabo E, Göbel TM, Schneider PM, Parson W. MtDNA diversity of Ghana: a forensic and phylogeographic view. Forensic Sci Int Genet. (2):244-9.

2. Thye T, Niemann S, Walter K, Homolka S, Intemann CD, Chinbuah MA, Enimil A, Gyapong J, Osei I, Owusu-Dabo E, Rüsch-Gerdes S, Horstmann RD, Ehlers S, Meyer CG(2011). Variant G57E of Mannose Binding Lectin Associated with Protection against Tuberculosis Caused by Mycobacterium africanum but not by M. tuberculosis. PLoS One. 2011;6(6):e20908.

3. Intemann CD, Thye T, Förster B, Owusu-Dabo E, Gyapong J, Horstmann RD, Meyer CG.(2011). MCP1 haplotypes associated with protection from pulmonary tuberculosis. BMC Genet. 12:34.

4. Ansong D, Asante KP, Vekemans J, Owusu SK, Owusu R, Brobby NA, Dosoo D, Osei-Akoto A, Osei-Kwakye K, Asafo-Adjei E, Boahen KO, Sylverken J, Adjei G, Sambian D, Apanga S, Kayan K, Janssens MH, Lievens MJ, Olivier AC, Jongert E, Dubois P, Savarese BM, Cohen J, Antwi S, Greenwood BM, Evans JA, Agbenyega T, Moris PJ, Owusu-Agyei S.(2011). T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children. PLoS One 6(4):e18891.

5. Schwandt HM, Creanga AA, Danso KA, Adanu RM, Agbenyega T, Hindin MJ.(2011). A comparison of women with induced abortion, spontaneous abortion and ectopic pregnancy in Ghana. Contraception 84(1):87-93.

6. Schuldt K, Kretz CC, Timmann C, Sievertsen J, Ehmen C, Esser C, Loag W, Ansong D, Dering C, Evans J, Ziegler A, May J, Krammer PH, Agbenyega T, Horstmann RD. (2011). A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria. PLoS Genet. (5):e1002066.

7. Ansong D, Asante KP, Vekemans J, Owusu SK, Owusu R, Brobby NA, Dosoo D, Osei-Akoto A, Osei-Kwakye K, Asafo-Adjei E, Boahen KO, Sylverken J, Adjei G, Sambian D, Apanga S, Kayan K, Janssens MH, Lievens MJ, Olivier AC, Jongert E, Dubois P, Savarese BM, Cohen J, Antwi S, Greenwood BM, Evans JA, Agbenyega T, Moris PJ, Owusu-Agyei S.(2011). T cell responses to the RTS,S/AS01(E) and RTS,S/AS02(D) malaria candidate vaccines administered according to different schedules to Ghanaian children. PLoS One 6(4):e18891.

8. Oni G, Fatusi A, Tsui A, Enquselassie F, Ojengbede O, Agbenyega T, Ojofeitimi E, Taulo F, Quakyi I.(2011). Strengthening public health education in population and reproductive health through an innovative academic partnership in Africa: the Gates partners experience. Glob. Public Health 6(2):193-209.

9. Debrah AY, Batsa L, Albers A, Mand S, Toliat MR, Nürnberg P, Adjei O, Hoerauf A, Pfarr K.(2011). Transforming growth factor-β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis. Hum. Immunol. 72(11):1143-8.

10. Hoerauf A, Pfarr K, Mand S, Debrah AY, Specht S.(2011). Filariasis in Africa–treatment challenges and prospects. Clin Microbiol Infect.17 (7):977-85. doi: 10.1111/j.1469-0691.2011.03586.x. Review.

11. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Albers A, Specht S, Klarmann U, Pfarr K, Adjei O, Hoerauf A.(2011). Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline. J Parasitol Res.201617.

12. Mand S, Debrah AY, Klarmann U, Mante S, Kwarteng A, Batsa L, Marfo-Debrekyei Y, Adjei O, Hoerauf A.(2011). The role of ultrasonography in the differentiation of the various types of filaricele due to bancroftian filariasis. Acta Trop. 120 Suppl 1:S23-32.

13. Canuti M, Eis-Huebinger AM, Deijs M, de Vries M, Drexler JF, Oppong SK, Müller MA, Klose SM, Wellinghausen N, Cottontail VM, Kalko EK, Drosten C, van der Hoek L.(2011). Two novel parvoviruses in frugivorous New and Old World bats. PLoS One 6(12):e29140.

14. Biome transitions as centres of diversity: habitat heterogeneity and diversity patterns of West African bat assemblages across spatial scales. Fahr Jakob; Kalko Elisabeth K. V. : ECOGRAPHY Volume: 34 Issue: 2 Pages: 177-195 DOI: 10.1111/j.1600-0587.2010.05510.x Published: APR 2011

15. Morphologically uniform bats Hipposideros aff. ruber (Hipposideridae) exhibit high mitochondrial genetic diversity in southeastern Senegal. Vallo Peter; Benda Petr; Martinkova Natalia; et al.

16. Vallo Peter; Benda Petr; Martinkova Natalia; et al. Morphologically uniform bats Hipposideros aff. ruber (Hipposideridae) exhibit high mitochondrial genetic diversity in southeastern Senegal. ACTA CHIROPTEROLOGICA Volume: 13 Issue:1Pages:79-88 DOI: 10.3161/150811011X578633 Published: 2011

17. Abdullah S, Adu-Sarkodie Y, Agbenyega O, Annan A, Baldwin H, Drosten C, Gloza-Rausch F, Kalko EKV, Klose SM, Kruppa T, Kubiczek K, Müller M, Nkrumah E, Oppong S, Owusu M (2011) Virus biology, host ecology and human behaviour as determinants of viral zoonoses. DFG Conference on African-German Cooperation in Infectology, Accra, Ghana, 21-24 March 2011, Vortrag und Poster.

18. Adu-Sarkodie Y, Agbenyega O, Annan A, Anti P, Baldwin H, Drosten C, Kalko E, Klose S, Kruppa T, Kubiczek K, Müller M, Nkrumah E, Oppong S, Owusu M (2011) Virus biology, host ecology and human behaviour. Mini Symposium‚ Parasites & Vertebrates‘, Ulm, Germany, 20 July 2011, Vortrag.

19. Adu-Sarkodie Y, Agbenyega O, Annan A, Anti P, Baldwin H, Drosten C, Kalko E, Klose S, Kruppa T, Kubiczek K, Müller M, Nkrumah E, Oppong S, Owusu M (2011) Virus biology, host ecology and human behaviour. Diversitas Workshop ‚Biodiversity and Infectious Diseases‘, Frankfurt, Germany, 28-29 November 2011, Chair, Poster.

20. Baldwin H, Klose S, Stow A, Drosten C, Oppong S, Adu-Sarkodie Y, Owusu M, Annan A, Nkrumah E, Gillings M, Kalko EKV (2011) Population genetics, phylogeography and disease: correlates of coronavirus dynamics and diversity in African leaf-nosed bats. Australasian Evolution Society Conference, Townsville QLD, 24-26 Sept 2011, Vortrag.

21. Klose SM, Nkrumah E, Owusu M, Baldwin H, Drosten C, Kalko EKV (2011) Coronaviral zoonoses in tropical bats. Annual Conference of the Society for Tropical Ecology, Frankfurt, 21-24 February 2011, Vortrag

22. Klose SM, Nkrumah E, Owusu M, Baldwin H, Drosten C, Kalko EKV (2011). Coronaviral zoonoses in tropical bats. Meeting of Bat Researchers in Germany 2011, Loccum, Germany, Vortrag

23. Abonuusum A, Owusu-Daako K, Tannich E, May J, Garms R, Kruppa T. Malaria transmission in two rural communities in the forest zone of Ghana. Parasitol Res 108:1465-1471 (2011)

24. Fobil J, Kraemer A, May J. Diagnostic Accuracy of Organ-Based Dissection Autopsies: A Study of Autopsy Procedures in Ghana. J Public Health Africa 2:16-20 (2011)

25. Krefis AC, Schwarz NG, Krüger A, Fobil J, Nkrumah B, Acquah S, Loag W, Sarpong N, Adu-Sarkodie Y, Ranft U, May J. Modelling the relationship between precipitation and malaria incidence in children from a holoendemic area in West Africa. Am J Trop Med Hyg 84:285-91 (2011)

26. Meyer CG, Fernandez MC, Intemann C, Kreuels B, Kobbe R, Kreuzberg C, Ayim M, Rüther A, Apiah-Thompson P, Agyim B, Loag W, Ehmen C, Adjei, S, Adjei O, May J. SNPs on chromosomal region 5q31-33 and malaria incidence in African children. Hum Mol Genet 20:1173-81 (2011)

27. Krefis AC, Schwarz NG, Nkrumah B, Acquah S, Loag W, Oldeland J, Sarpong N, Adu-Sarkodie Y, Ranft U, May J. Spatial analysis of land cover determinants of malaria incidence in the Ashanti Region, Ghana. PloS ONE 23;6:e17905 (2011)

28. Fobil J, Kraemer A, Meyer CG, May J. Neighborhood Urban Environmental Quality Conditions are likely to drive Malaria and Diarrhea Mortality in Accra, Ghana. J Environ Public Health 2011:484010 (2011)

29. Nkrumah B, Nguah SB, Sarpong N, Decker D, Idriss A, May J, Adu-Sarkodie Y. Hemoglobin estimation by the HemoCue(R) portable hemoglobin photometer in a resource poor setting. BMC Clin Pathol 11:5 (2011)

30. Nkrumah B, Acquah SEK, Lukeman I, Blay SN, Agyekum A, May J, Brattig N, Tannich E, Adu-Sarkodie Y, Hünger F. Comparative evaluation of two rapid field tests for malaria diagnosis: Partec Rapid Malaria Test® and Binax Now® Malaria Rapid Diagnostic Test. BMC Infect Dis 11:143 (2011)

31. Schuldt K, Kretz CC, Timmann C, Sievertsen J, Ehmen C, Esser C, Evans J, May J, Loag W, Ansong D, Dering C, Ziegler A, Krammer PH, Agbenyega T, Horstmann RD. A -436c>A Polymorphism In The Human Fas Gene Promoter Associated With Severe Childhood Malaria. PloS Genet 7:e1002066 (2011)

32. Drexler JF, Baumgarte S, Eschbach-Bludau M, Simon A, Kemen C, Bode U, Eis-Hübinger AM, Madea B, Drosten C. (2011). Human cardioviruses, meningitis, and sudden infant death syndrome in children.Emerg Infect Dis.17(12):2313-5. doi: 10.3201/eid1712.111037.

33. Shuaib, FMB, Ehiri, JE, Yatich, NJ, Funkhouser, E., Person, SD, Wilson, C., Turpin, C., Agbenyega, T., Williams, JH, Qian, G., Wang, J-S., and Jolly, PE(2011). Socio-demographic determinants of aflatoxin B1-lysine adduct levels among pregnant women in Kumasi, Ghana (in press, Ghana Medical Journal).

34. Obuseh, F., Jolly, P.E., Preko P.O., Kulczycki A., Ehiri J., Waterbor J., Jiang, Y., Piyathilake C.J. Desmond R.A.(2011). Aflatoxin exposure and health characteristics associated with vitamin A and E levels in HIV positive Ghanaians. Journal of the International AIDS Society, 14:53 doi:10.1186/1758-2652-14-53.

35. Jolly, P.E., Shuaib, F., Jiang, Y., Preko, P.O., Baidoo, J., Stiles, J.K., Wang, J-S., Phillips, T.D, and Williams, J.H.(2011). Association of viral load and liver function with high aflatoxin levels in HIV positive Ghanaians. Food Additives and Contaminants Part A. 28(9):1224-34.

36. Obuseh, F., Jolly, P.E., Jiang, Y., Shuaib, F., Waterbor, J., Ellis, W.O., Piyathilake, C., Ellis W.O., Desmond, R.A., Afriyie-Gyawu, E., and Phillips, T.(2011). Relationship between aflatoxin B1 albumin adducts in plasma, aflatoxin M1 in urine and vitamin A and E levels in Ghanaians. International Journal of Vitamin and Nutrition Research 80:355-368

37. Keenan, J., Jolly, P.E., Preko, P., Baidoo, J., Jiang, Y., McGwin, G. Jr.(2011). Association between aflatoxin B1 albumin adduct levels and tuberculosis infection among HIV+ Ghanaians. Archives of Clinical Microbiology Vol. 2, No. 3:3, doi:10:3823/230.

38. Owusu-Dabo E, Lewis S, McNeill A, Gilmore A, Britton J.(2011). Support for smoke-free policy, and awareness of tobacco health effects and use of smoking cessation therapy in a developing country. BMC Public Health 11:572.

39. Sarfo FS, Lavender CJ, Fyfe JA, Johnson PD, Stinear TP, Phillips RO. Mycobacterium ulcerans DNA not detected in faecal samples from Buruli ulcer patients:results of a pilot study. PLoS One. 2011 May4;6(5):e19611.

40. Kariuki T, Phillips R, Njenga S, Olesen OF, Klatser PR, Porro R, Lock S, Cabral MH,Gliber M, Hanne D. Research and capacity building for control of neglected tropical diseases:the need for a different approach. PLoS Negl Trop Dis. 2011;5 (5):e1020.

41. I Bates, R Phillips, R Martin-Peprah, G Kibiki, O Gaye, K Phiri , H Tagbor, S Purnell Assessing and strengthening African universities’ capacity for doctoral programmes PLoS Medicine 2011 Sep;8 (9) 31001068

42. Sarfo FS, Le Chevalier F, Aka N, Phillips RO, Amoako Y, Boneca IG, Lenormand P,Dosso M, Wansbrough-Jones M, Veyron-Churlet R, Guenin-Macé L, Demangel C. Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications fordiagnosis and disease monitoring. PLoS Negl Trop Dis. 2011 Jul;5(7): e1237.

43. Mamoojee Y, Shakoor S, Gorton RL, Sarfo S, Appiah LT, Norman B, Balakrishnan I, Phillips R, Chadwick D. Short Communication: Low seroprevalence of cryptococcal antigenaemia in patients with advanced HIV infection enrolling in an antiretroviral programme in Ghana.Trop Med Int Health. 2011 Jan;16(1):53-6.

44. Adegnika AA, Luty AJF, Grobusch MP, Ramharter M, Yazdanbakhs M, Kremsner PG, Schwarz NG. ABO blood group and the risk of placental malaria in sub-Saharan Africa. Malaria J 2011, 10:101

45. Krefis AC, Schwarz NG, Nkrumah B, Acquah S, Loag W, Oldeland J, Sarpong N, Adu-Sarkodie YA, Ranft U, May J, Spatial Analysis of Land Cover Determinants of Malaria Incidence in the Ashanti Region, Ghana. Plos One 2011 published online in March 2011

46. Krefis AC, Schwarz NG, Krüger A, Fobil J, Nkrumah B, Acquah S, Loag W, Sarpong N, Adu-Sarkodie YA, Ranft U, May J, Modeling the relationship between precipitation and malaria incidence in children from a holoendemic area in West Africa. Am J Trop Med Hyg 2011, 84(2): 285-91

47. Harrison I, Odame Phillips R, Gonzalez A, Sarfo F, Garcia A, Candotti D, Allain J-P, Chadwick D, Geretti AM. Impact of HIV Infection on HBV polymerase and surface variability among patients accessing 3TC-containing ART in Ghana. 18th Conference on Retroviruses and Opportunistic Infections, Boston 2011.

48. Debrah AY, Batsa L, Albers A, Mand S, Toliat MR, Nürnberg P, Adjei O, Hoerauf A, Pfarr K. Transforming growth factor-β1 variant Leu10Pro is associated with both lack of microfilariae and differential microfilarial loads in the blood of persons infected with lymphatic filariasis. Hum Immunol. 2011 Nov;72(11): 1143-8.

49. Debrah AY, Mand S, Marfo-Debrekyei Y, Batsa L, Albers A, Specht S, Klarmann U, Pfarr K, Adjei O, Hoerauf A. Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline. J Parasitol Res. 2011;2011:201617.

50. Kobbe R, Hogan B, Adjei S, Klein P, Kreuels B, Loag W, Adjei O, May J. Follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants. J Infect Dis. 2011 Feb 15;203(4):556-60.

Publications 2012

1. Frickmann H, Schwarz NG, Girmann M, Hagen RM, Poppert S, Crusius S, Podbielski A, Heriniaina JN, Razafindrabe T, Rakotondrainiarivelo JP, May J, Rakotozandrindrainy R. Serological survey of HIV and syphilis in pregnant women in Madagascar.Trop Med Int Health. 2013 Jan;18(1):35-9. doi: 10.1111/tmi.12007. Epub 2012 Oct 24.

2. Schwarz NG, Girmann M, Randriamampionona N, Bialonski A, Maus D, Krefis AC, Njarasoa C, Rajanalison JF, Ramandrisoa HD, Randriarison ML, May J, Schmidt-Chanasit J, Rakotozandrindrainy R. Seroprevalence of antibodies against Chikungunya, Dengue, and Rift Valley fever viruses after febrile illness outbreak, Madagascar.Emerg Infect Dis. 2012 Nov;18(11):1780-6. doi: 10.3201/eid1811.111036.

3. Drexler JF, Reber U, Muth D, Herzog P, Annan A, Ebach F, Sarpong N, Acquah S, Adlkofer J, Adu-Sarkodie Y, Panning M, Tannich E, May J, Drosten C, Eis-Hübinger AM.Human parvovirus 4 in nasal and fecal specimens from children, Ghana. Emerg Infect Dis. 2012 Oct;18(10):1650-3. doi: 10.3201/eid1810.111373.

4. May J, Drexler JF, Reber U, Sarpong N, Adjei O, Panning M, Drosten C, Eis-Hübinger AM.Human parvovirus 4 viremia in young children, Ghana. Emerg Infect Dis. 2012 Oct;18(10):1690-2. doi: 10.3201/eid1810.111836.

5. Nielsen MV, Sarpong N, Krumkamp R, Dekker D, Loag W, Amemasor S, Agyekum A, Marks F, Huenger F, Krefis AC, Hagen RM, Adu-Sarkodie Y, May J, Schwarz NG. Incidence and characteristics of bacteremia among children in Rural Ghana. PLoSOne.2012;7(9):e44063. doi: 10.1371/journal.pone.0044063. Epub 2012 Sep 10.

6. Timmann C, Thye T, Vens M, Evans J, May J, Ehmen C, Sievertsen J, Muntau B, Ruge G, Loag W, Ansong D, Antwi S, Asafo-Adjei E, Nguah SB, Kwakye KO, Akoto AO, Sylverken J, Brendel M, Schuldt K, Loley C, Franke A, Meyer CG, Agbenyega T, Ziegler A, Horstmann RD. Genome-wide association study indicates two novel resistance loci for severe malaria. Nature. 2012 Sep20;489(7416):443-6. doi: 10.1038/nature11334. Epub 2012 Aug 15.

7. Vinnemeier CD, Schwarz NG, Sarpong N, Loag W, Acquah S, Nkrumah B, Huenger F, Adu-Sarkodie Y, May J. Predictive value of fever and palmar pallor for P. falciparum parasitaemia in children from an endemic area. PLoSOne.2012;7(5):e36678. doi: 10.1371/journal.pone.0036678. Epub 2012 May 4.

8. Afrane YA, Lawson BW, Brenya R, Kruppa T, Yan G. The ecology of mosquitoes in an irrigated vegetable farm in Kumasi, Ghana: abundance, productivity and survivorship. Parasite Vectors. 2012 Oct 15;5:233. doi: 10.1186/1756-3305-5-233.

9. Maia MF, Abonuusum A, Lorenz LM, Clausen PH, Bauer B, Garms R, Kruppa T. The effect of deltamethrin-treated net fencing around cattle enclosures on outdoor-biting mosquitoes in Kumasi, Ghana. PLoSOne.2012;7(9):e45794. doi: 10.1371/journal.pone.0045794. Epub 2012 Sep 19.

10. Drexler JF, Corman VM, Müller MA, Maganga GD, Vallo P, Binger T, Gloza-Rausch F, Rasche A, Yordanov S, Seebens A, Oppong S, Adu Sarkodie Y, Pongombo C, Lukashev AN, Schmidt-Chanasit J, Stöcker A, Carneiro AJ, Erbar S, Maisner A, Fronhoffs F, Buettner R, Kalko EK, Kruppa T, Franke CR, Kallies R, Yandoko ER, Herrler G, Reusken C, Hassanin A, Krüger DH, Matthee S, Ulrich RG, Leroy EM, Drosten C. Bats host major mammalian paramyxoviruses. Nat Commun. 2012 Apr 24;3:796. doi: 10.1038/ncomms1796.

11. Mamoojee Y, Tan G, Gittins S, Sarfo S, Stephenson L, Carrington D, Bedu-Addo G, Phillips R, Appiah LT, Chadwick D. Diagnosis of treponemal co-infection in HIV-infected West Africans. Trop Med Int Health. 2012 Sep 20. doi: 10.1111/j.1365-3156.2012.03090.x. [Epub ahead of print]

12. Beissner M, Symank D, Phillips RO, Amoako YA, Awua-Boateng NY, Sarfo FS, Jansson M, Huber KL, Herbinger KH, Battke F, Löscher T, Adjei O, Bretzel G. Detection of viable Mycobacterium ulcerans in clinical samples by a novel combined 16S rRNA reverse transcriptase/IS2404 real-time qPCR assay. PLoS Negl Trop Dis. 2012;6(8):e1756. doi: 10.1371/journal.pntd.0001756. Epub 2012 Aug 28.

13. Bindt C, Appiah-Poku J, Te Bonle M, Schoppen S, Feldt T, Barkmann C, Koffi M, Baum J, Nguah SB, Tagbor H, Guo N, N’Goran E, Ehrhardt S; International CDS Study Group. Antepartum depression and anxiety associated with disability in African women: cross-sectional results from the CDS study in Ghana and Côte d’Ivoire. PLoS One. 2012;7(10):e48396. doi: 10.1371/journal.pone.0048396. Epub 2012 Oct 26.

14. Nguah SB, Feldt T, Hoffmann S, Pelletier D, Ansong D, Sylverken J, Mehrfar P, Herr J, Thiel C, Ehrhardt S, Burchard GD, Cramer JP. Cardiac function in Ghanaian children with severe malaria.Intensive Care Med. 2012 Dec;38(12):2032-41. doi: 10.1007/s00134-012-2676-z. Epub 2012 Aug 14.

15. Bonney JH, Kwame-Aryee RA, Obed S, Tamatey AA, Barnor JS, Armah NB, Oppong SA, Osei-Kwesi M. Fatal Hepatitis E viral infection in pregnant women in Ghana: a case series. BMC Res Notes. 2012 Sep 3;5:478. doi: 10.1186/1756-0500-5-478.

16. Drexler JF, Seelen A, Corman VM, Fumie Tateno A, Cottontail V, Melim Zerbinati R, Gloza-Rausch F, Klose SM, Adu-Sarkodie Y, Oppong SK, Kalko EK, Osterman A, Rasche A, Adam A, Müller MA, Ulrich RG, Leroy EM, Lukashev AN, Drosten C. Bats worldwide carry Hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae. J Virol. 2012 Sep;86(17):9134-47. doi: 10.1128/JVI.00800-12. Epub 2012 Jun 13.

17. Kwofie TB, Anane YA, Nkrumah B, Annan A, Nguah SB, Owusu M. Respiratory viruses in children hospitalized for acute lower respiratory tract infection in Ghana. Virol J. 2012 Apr 10;9:78. doi: 10.1186/1743-422X-9-78.

18. Thye T, Owusu-Dabo E, Vannberg FO, van Crevel R, Curtis J, Sahiratmadja E, Balabanova Y, Ehmen C, Muntau B, Ruge G, Sievertsen J, Gyapong J, Nikolayevskyy V, Hill PC, Sirugo G, Drobniewski F, van de Vosse E, Newport M, Alisjahbana B, Nejentsev S, Ottenhoff TH, Hill AV, Horstmann RD, Meyer CG. Common variants at 11p13 are associated with susceptibility to tuberculosis. Nat Genet. 2012 Feb 5;44(3):257-9. doi: 10.1038/ng.1080.

19. Fendt L, Röck A, Zimmermann B, Bodner M, Thye T, Tschentscher F, Owusu-Dabo E, Göbel TM, Schneider PM, Parson W. MtDNA diversity of Ghana: a forensic and phylogeographic view. Forensic Sci Int Genet. 2012 Mar;6(2):244-9. doi: 10.1016/j.fsigen.2011.05.011. Epub 2011 Jun 30.

20. Shuaib FM, Ehiri JE, Jolly P, Zhang Q, Emusu D, Ngu J, Foushee H, Katongole D, Kirby R, Wabwire-Mangen F. Sexual violence and associated factors among women in HIV discordant and concordant relationships in Uganda. Int J Adolesc Med Health. 2012;24(2):125-33. doi: 10.1515/ijamh.2012.019. Epub 2011 Nov 29.

21. Bromfield S, Keenan J, Jolly P, McGwin G Jr. A suggested association between hypothyroidism and age-related macular degeneration. Curr Eye Res. 2012 Jun;37(6):549-52. doi: 10.3109/02713683.2011.647223.

22. Frojo GA, Rogers NG, Mazariegos M, Keenan J, Jolly P. Relationship between the nutritional status of breastfeeding Mayan mothers and their infants in Guatemala. Matern Child Nutr. 2012 Mar 28. doi: 10.1111/j.1740-8709.2012.00404.x. [Epub ahead of print]

23. Owusu M, Nguah SB, Boaitey YA, Badu-Boateng E, Abubakr AR, Lartey RA, Adu-Sarkodie Y. Aetiological agents of cerebrospinal meningitis: a retrospective study from a teaching hospital in Ghana. Ann Clin Microbiol Antimicrob. 2012 Oct 4;11:28. doi: 10.1186/1476-0711-11-28.

24. RTS,S Clinical Trials Partnership: Agnandji ST, Lell B, Fernandes JF, Abossolo BP, Methogo BG, Kabwende AL, Adegnika AA, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Machevo S, Acacio S, Bulo H, Sigauque B, Macete E, Alonso P, Abdulla S, Salim N, Minja R, Mpina M, Ahmed S, Ali AM, Mtoro AT, Hamad AS, Mutani P, Tanner M, Tinto H, D’Alessandro U, Sorgho H, Valea I, Bihoun B, Guiraud I, Kaboré B, Sombié O, Guiguemdé RT, Ouédraogo JB, Hamel MJ, Kariuki S, Oneko M, Odero C, Otieno K, Awino N, McMorrow M, Muturi-Kioi V, Laserson KF, Slutsker L, Otieno W, Otieno L, Otsyula N, Gondi S, Otieno A, Owira V, Oguk E, Odongo G, Woods JB, Ogutu B, Njuguna P, Chilengi R, Akoo P, Kerubo C, Maingi C,Lang T, Olotu A, Bejon P, Marsh K, Mwambingu G, Owusu-Agyei S, Asante KP, Osei-Kwakye K, Boahen O, Dosoo D, Asante I, Adjei G, Kwara E, Chandramohan D, Greenwood B, Lusingu J, Gesase S, Malabeja A, Abdul O, Mahende C, Liheluka E, Malle L, Lemnge M, Theander TG, Drakeley C, Ansong D, Agbenyega T, Adjei S, Boateng HO, Rettig T, Bawa J, Sylverken J, Sambian D, Sarfo A, Agyekum A, Martinson F, Hoffman I, Mvalo T, Kamthunzi P, Nkomo R, Tembo T, Tegha G, Tsidya M, Kilembe J, Chawinga C, Ballou WR, Cohen J, Guerra Y, Jongert E, Lapierre D, Leach A, Lievens M, Ofori-Anyinam O, Olivier A, Vekemans J, Carter T, Kaslow D, Leboulleux D, Loucq C, Radford A, Savarese B, Schellenberg D, Sillman M, Vansadia P. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N Engl J Med. 2012 Dec 13;367(24):2284-95. doi: 10.1056/NEJMoa1208394. Epub 2012 Nov 9.

25. Von Seidlein L, Olaosebikan R, Hendriksen IC, Lee SJ, Adedoyin OT, Agbenyega T, Nguah SB, Bojang K, Deen JL, Evans J, Fanello CI, Gomes E, Pedro AJ, Kahabuka C, Karema C, Kivaya E, Maitland K, Mokuolu OA, Mtove G, Mwanga-Amumpaire J, Nadjm B, Nansumba M, Ngum WP, Onyamboko MA, Reyburn H, Sakulthaew T, Silamut K, Tshefu AK, Umulisa N, Gesase S, Day NP, White NJ, Dondorp AM. Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trial. Clin Infect Dis. 2012 Apr;54(8):1080-90. doi: 10.1093/cid/cis034. Epub 2012 Mar 12.

26. Tougher S; ACTwatch Group, Ye Y, Amuasi JH, Kourgueni IA, Thomson R, Goodman C, Mann AG, Ren R, Willey BA, Adegoke CA, Amin A, Ansong D, Bruxvoort K, Diallo DA, Diap G, Festo C, Johanes B, Juma E, Kalolella A, Malam O, Mberu B, Ndiaye S, Nguah SB, Seydou M, Taylor M, Rueda ST, Wamukoya M, Arnold F, Hanson K. Effect of the Affordable Medicines Facility–malaria (AMFm) on the availability, price, and market share of quality-assured artemisinin-based combination therapies in seven countries: a before-and-after analysis of outlet survey data. Lancet. 2012 Dec 1;380(9857):1916-26. doi: 10.1016/S0140-6736(12)61732-2. Epub 2012 Oct 31.

27. Cook-Huynh M, Ansong D, Steckelberg RC, Boakye I, Seligman K, Appiah L, Kumar N, Amuasi JH. Prevalence of hypertension and diabetes mellitus in adults from a rural community in Ghana. Ethn Dis. 2012 Summer;22(3):347-52.

28. Conor R. Caffrey, Mark J. Taylor, Louise Ford, Achim Hoerauf, Ken Pfarr, Jeremy M. Foster, Sanjay Kumar, Barton E. Slatko Drugs and Targets to Perturb the Symbiosis of Wolbachia and Filarial Nematodes. Published Online: 23 AUG 2012DOI: 10.1002/9783527652969.ch15

29. Andrea Schiefer, Alexander Schmitz, Till F. Schäberle, Sabine Specht, Christine Lämmer, Kelly L. Johnston, Dmitry G. Vassylyev, Gabriele M. König, Achim Hoerauf and Kenneth Pfarr
Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo. http://dx.doi.org/10.1016/j.chembiol.2012.11.009,

30. Hübner MP, Shi Y, Torrero MN, Mueller E, Larson D, Soloviova K, Gondorf F, Hoerauf A, KilloranJ. KE, Stocker T, Davies SJ, KV and Mitre E. Helminth Protection against Autoimmune Diabetes in Nonobese Diabetic Mice Is Independent of a Type 2 Immune Shift and Requires TGF-β. J Immunol. 2012 Jan 15;188(2):559-68. doi: 10.4049/jimmunol.1100335. Epub 2011 Dec 14.

31. MandS, Debrah AY, Klarmann U,Batsa L, Marfo-Debrekyei Y, KwartengA, Specht S,Belda-Domene A, Fimmers R, Taylor M,Adjei O, and HoeraufA, Doxycycline Improves Filarial Lymphedema Independent of Active Filarial Infection: A Randomized Controlled Trial. Clin Infect Dis. 2012 Sep;55(5):621-30. doi: 10.1093/cid/cis486. Epub 2012 May 18.

32. Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, 
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33. Lamb TJ, Specht S, Hoerauf A. Nematoda: Filarial Nematodes. Published Online: 10 AUG 2012DOI: 10.1002/9781118393321.ch11

34. Hussain H, Specht S, Sarite SR, Hoerauf A, Krohn K. New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain. Eur J Med Chem. 2012 Aug;54:936-42. doi: 10.1016/j.ejmech.2012.06.046. Epub 2012 Jul 3.

35. Ziewer S, Hübner MP, Dubben B, Hoffmann WH, Bain O, Martin C, Hoerauf A, Specht S. Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis. PLoS Negl Trop Dis. 2012;6(3):e1558. doi: 10.1371/journal.pntd.0001558. Epub 2012 Mar 6.

36. Albers A, Esum ME, Tendongfor N, Enyong P, Klarmann U, Wanji S, Hoerauf A and Pfarr K. Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host. Parasit Vectors. 2012 Jan 11;5:12. doi: 10.1186/1756-3305-5-12.

37. Tendongfor N, Wanji S, Ngwa JC, Esum ME, Specht S, Enyong P, MatthaeiKI and Hoerauf A. The human parasite Loa loa in cytokine andcytokine receptor gene knock out BALB/c mice:survival, development and localization. Parasit Vectors. 2012 Feb 21;5:43. doi: 10.1186/1756-3305-5-43.

38. Pfarr KM, Hörauf A, König, Maria G, Specht S, Schiefer A, Schäberle TF, Schmitz A, Kehraus S. Compounds for use in the treatment of filariasis. European Patent Application EP2520293,Application Number: EP20110164963, Publication Date:11/07/2012

39. Bindt C, Appiah-Poku J, Bonle MT, Schoppen S, Feldt T, Barkmann C, Koffi M, Baum J, Nguah SB, Tagbor H, Guo N, N’Goran E, Ehrhardt S. Antepartum Depression and Anxiety Associated with Disability in African Women: Cross-Sectional Results from the CDS Study in Ghana and Côte d’Ivoire. PLoS One. 2012;7(10):e48396. doi: 10.1371/journal.pone.0048396. Epub 2012 Oct 26.